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    l(2)k09848 lethal (2) k09848 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(2)k09848provided by FlyBase
    Official Full Name
    lethal (2) k09848provided by FlyBase
    Primary source
    FLYBASE:FBgn0284246
    Locus tag
    Dmel_CG7845
    See related
    AllianceGenome:FB:FBgn0284246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG745; CG7845; Dmel\CG7845; NSA1; WDR74
    Summary
    Involved in muscle cell cellular homeostasis. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in organism. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(2)k09848 in Genome Data Viewer
    Location:
    42A9-42A9; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6074471..6076367, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1961976..1963872, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene CCHamide-2 receptor Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44131 Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. Marrone AK, et al. BMC Neurosci, 2011 Sep 26. PMID 21943192, Free PMC Article
    2. Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Kucherenko MM, et al. Dev Biol, 2011 Apr 15. PMID 21256839
    3. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Sanchez CG, et al. Cell Stem Cell, 2016 Feb 4. PMID 26669894, Free PMC Article
    4. Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex. Kucherenko MM, et al. PLoS One, 2008 Jun 11. PMID 18545683, Free PMC Article
    5. Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth. Furrer M, et al. J Biol Chem, 2010 Dec 17. PMID 20937797, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (2) k09848
    Names
    CG7845-PA
    CG7845-PB
    l(2)k09848-PA
    l(2)k09848-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6074471..6076367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201938.2 → NP_001188867.1  lethal (2) k09848, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4B2
      Conserved Domains (3) summary
      COG2319
      Location:36 → 327
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:146 → 184
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:55 → 318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_136356.4 → NP_610200.1  lethal (2) k09848, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4B2
      Related
      FBpp0085359
      Conserved Domains (3) summary
      COG2319
      Location:36 → 327
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:146 → 184
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:55 → 318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4B2 Q7K4B2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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