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    CG1236 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1236provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037370
    Locus tag
    Dmel_CG1236
    See related
    AllianceGenome:FB:FBgn0037370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1236
    Summary
    Predicted to enable glyoxylate reductase (NADPH) activity and hydroxypyruvate reductase (NADH) activity. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; gland; hindgut proper primordium; and salivary gland body primordium. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1236 in Genome Data Viewer
    Location:
    83C1-83C1; 3-47.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5736748..5738013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1562470..1563735)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44924 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Symplekin Neighboring gene MLF1-adaptor molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Tatomer DC, et al. Nucleus, 2014. PMID 25493544, Free PMC Article
    2. Evolutionary changes in cis and trans gene regulation. Wittkopp PJ, et al. Nature, 2004 Jul 1. PMID 15229602
    3. Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Yu J, et al. Development, 2016 Aug 15. PMID 27471256
    4. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Juhász G, et al. Cell Death Differ, 2007 Jun. PMID 17363962, Free PMC Article
    5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1236-PA
    NP_649579.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5736748..5738013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141322.2 → NP_649579.2  uncharacterized protein Dmel_CG1236 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649579.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I725, Q8MR05
      Related
      FBpp0078370
      Conserved Domains (2) summary
      COG1052
      Location:27 → 338
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:27 → 338
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I725 Q8I725
    Q8MR05 Q8MR05

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