Pen Pendulin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Penprovided by FlyBase
Official Full Name: Pendulinprovided by FlyBase
Primary source: FLYBASE:FBgn0287720
Locus tag: Dmel_CG4799
See related: AllianceGenome:FB:FBgn0287720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2.1; alpha2; alpha2A-Kap; alphaKap2; anon-WO0140519.258; bs29g06.y1; CG4799; Dalpha2; Dimp-alpha2; Dmel\CG4799; DPend; Imp alpha-2; imp alpha2; Imp alpha2; imp-alpha2; Imp-alpha2; impalpha2; Impalpha2; IMPalpha2; importin alpha2/pendulin; importin-alpha; Kap alpha2; Kap-alpha2; Kpna2; l(2)144/1; l(2)k06324; l(2)k14401; mbmB; mbmB[N806]; mbm[B]; oho-31; oho31; Oho31; OHO31; pen; PEN; pen-2; Rch1; rem
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in several processes, including NLS-bearing protein import into nucleus; germ cell development; and gravitaxis. Located in cytoplasm and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval midline of ventral nerve cord; ganglia; imaginal disc; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31A1-31A2; 2-39 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10056900..10060095)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10056900..10060095)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Importin-alpha2 mediates brain development, learning and memory consolidation in Drosophila.
Title: Importin-α2 mediates brain development, learning and memory consolidation in Drosophila.
Maternal Nanos inhibits Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
Title: Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline.
Importin-alpha2 is needed for some processes in the development of both the nervous system and the larval musculature
Title: Drosophila Importin-α2 is involved in synapse, axon and muscle development.
Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway.
Title: The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development.
each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
Imp-alpha 2 protein plays a critical role in Kelch function by regulating its deposition on ring canals during their assembly.
Title: Importin-alpha 2 is critically required for the assembly of ring canals during Drosophila oogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pendulin

Names: CG4799-PA; Importin-a2; Importin-alpha; Importin-alpha2; Pen-PA; alpha-importin; i; importin alpha; importin alpha2; lethal (2) k06324; mushroom body miniature B; mushroom-body-miniature-B; penduline; reduced-mushroom-bodies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10056900..10060095

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057693.5 → NP_477041.1 pendulin [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477041.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52295, Q24431, Q95R96, Q9VL45

Related

FBpp0079527

Conserved Domains (3) summary

COG5064
Location:2 → 517

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00044
Location:70 → 102

HEAT; HEAT repeat [structural motif]

sd00043
Location:108 → 140

ARM; armadillo repeat [structural motif]