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    del deadlock [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    delprovided by FlyBase
    Official Full Name
    deadlockprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086251
    Locus tag
    Dmel_CG9252
    See related
    AllianceGenome:FB:FBgn0086251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9252; Del; DEL; Dmel\CG9252
    Summary
    Involved in several processes, including fusome organization; oogenesis; and positive regulation of piRNA transcription. Located in centrosome; heterochromatin; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See del in Genome Data Viewer
    Location:
    39A4-39A5; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21145137..21148546, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21145137..21148546, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dynamin associated protein 160 Neighboring gene ncRNA Neighboring gene porthos Neighboring gene E2F transcription factor 2 Neighboring gene M-phase phosphoprotein 6 Neighboring gene Coenzyme Q3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptive Evolution Leads to Cross-Species Incompatibility in the piRNA Transposon Silencing Machinery. Parhad SS, et al. Dev Cell, 2017 Oct 9. PMID 28919205, Free PMC Article
    2. Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification. Yu B, et al. EMBO Rep, 2018 Jul. PMID 29858487, Free PMC Article
    3. Protein-Protein Interactions Shape Genomic Autoimmunity in the Adaptively Evolving Rhino-Deadlock-Cutoff Complex. Kelleher ES. Genome Biol Evol, 2021 Jul 6. PMID 34115120, Free PMC Article
    4. Induction of Transposon Silencing in the Drosophila Germline. Ryazansky SS, et al. Biochemistry (Mosc), 2017 May. PMID 28601066
    5. Adaptive Evolution Targets a piRNA Precursor Transcription Network. Parhad SS, et al. Cell Rep, 2020 Feb 25. PMID 32101744, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we determine the crystal structures of Rhino-Deadlock complex in Drosophila melanogaster and simulans In both species, one Rhino binds the N-terminal helix-hairpin-helix motif of one Deadlock protein through a novel interface formed by the beta-sheet in the Rhino chromoshadow domain
      Title: Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification.
    2. Analysis of piRNA clusters in the Drosophila ovary shows that hallmarks of RNA Polymerase II (Pol II) transcription are fundamentally different at uni-strand versus dual-strand clusters. Genome-wide, piRNA production from dual-strand clusters requires the RDC complex consisting of Rhi, Deadlock (Del), and Cuff.
      Title: The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in fusome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte localization involved in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of piRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deadlock
    Names
    CG9252-PA
    CG9252-PB
    CG9252-PC
    del-PA
    del-PB
    del-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21145137..21148546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273737.1 → NP_001260666.1  deadlock, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P81, Q9VIF5
      UniProtKB/TrEMBL
      M9PDK1
      Conserved Domains (1) summary
      pfam07964
      Location:169 → 453
      Red1; Rec10 / Red1

    2. NM_001273736.1 → NP_001260665.1  deadlock, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDW9
      Conserved Domains (1) summary
      pfam07964
      Location:169 → 455
      Red1; Rec10 / Red1

    3. NM_136247.3 → NP_610091.2  deadlock, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610091.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P81, Q9VIF5
      UniProtKB/TrEMBL
      M9PDK1
      Related
      FBpp0081030
      Conserved Domains (1) summary
      pfam07964
      Location:169 → 453
      Red1; Rec10 / Red1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDK1 M9PDK1
    M9PDW9 M9PDW9
    Q9VIF5.2 Q9VIF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools