CDase Ceramidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CDaseprovided by FlyBase
Official Full Name: Ceramidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0039774
Locus tag: Dmel_CG1471
See related: AllianceGenome:FB:FBgn0039774
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.407; cdase; Cdase; CG1471; Dmel\CG1471; fcd; slab
Summary: Enables N-acylsphingosine amidohydrolase activity. Involved in several processes, including hatching behavior; photoreceptor cell maintenance; and synaptic vesicle fusion to presynaptic active zone membrane. Located in cytoplasm and extracellular region. Is expressed in adult head; embryonic precursor of adult hindgut; embryonic/larval hemocyte; plasmatocyte primordium; and posterior midgut primordium. Used to study cardiomyopathy. Orthologous to human ASAH2 (N-acylsphingosine amidohydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99F5-99F6; 3-100 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30459521..30465736)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26285243..26291458)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show the neutral ceramidase gene CDase encodes the protein that is responsible for all measurable ceramidase activity in Drosophila; studies show strong genetic interaction of Bwa with CDase and the ceramide kinase gene
Title: CDase is a pan-ceramidase in Drosophila.
SLAB ceramidase function controls presynaptic terminal sphingolipid composition to regulate vesicle fusion and trafficking, and thus the strength and reliability of synaptic transmission
Title: Ceramidase regulates synaptic vesicle exocytosis and trafficking.
Data report the molecular cloning and characterization of the Drosophila neutral ceramidase.
Title: Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acylsphingosine amidohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acylsphingosine amidohydrolase activity	IEA Inferred from Electronic Annotation more info
enables N-acylsphingosine amidohydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ceramide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hatching behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ceramidase

Names: CDase-PA; CDase-PB; CDase-PC; CDase-PD; CDase-PE; CDase-PF; CG1471-PA; CG1471-PB; CG1471-PC; CG1471-PD; CG1471-PE; CG1471-PF; slug-a-bed

NP_001263109.1

EC 3.5.1.23

NP_651797.1

EC 3.5.1.23

NP_733367.1

EC 3.5.1.23

NP_733368.1

EC 3.5.1.23

NP_733369.1

EC 3.5.1.23

NP_733370.1

EC 3.5.1.23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30459521..30465736

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276180.1 → NP_001263109.1 ceramidase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263109.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YTD8, Q86NP1, Q9VA70

UniProtKB/TrEMBL

A4V3N7

Conserved Domains (3) summary

PTZ00487
Location:24 → 701

PTZ00487; ceramidase; Provisional

pfam04734
Location:25 → 538

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:540 → 701

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_170488.2 → NP_733367.1 ceramidase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733367.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YTD8, Q86NP1, Q9VA70

UniProtKB/TrEMBL

A4V3N7

Related

FBpp0085007

Conserved Domains (3) summary

PTZ00487
Location:24 → 701

PTZ00487; ceramidase; Provisional

pfam04734
Location:25 → 538

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:540 → 701

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_170491.2 → NP_733370.1 ceramidase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733370.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YTD8, Q86NP1, Q9VA70

UniProtKB/TrEMBL

A4V3N7

Related

FBpp0085011

Conserved Domains (3) summary

PTZ00487
Location:24 → 701

PTZ00487; ceramidase; Provisional

pfam04734
Location:25 → 538

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:540 → 701

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_170489.2 → NP_733368.1 ceramidase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733368.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YTD8, Q86NP1, Q9VA70

UniProtKB/TrEMBL

A4V3N7

Related

FBpp0085009

Conserved Domains (3) summary

PTZ00487
Location:24 → 701

PTZ00487; ceramidase; Provisional

pfam04734
Location:25 → 538

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:540 → 701

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_170490.2 → NP_733369.1 ceramidase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733369.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YTD8, Q86NP1, Q9VA70

UniProtKB/TrEMBL

A4V3N7

Related

FBpp0085010

Conserved Domains (3) summary

PTZ00487
Location:24 → 701

PTZ00487; ceramidase; Provisional

pfam04734
Location:25 → 538

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:540 → 701

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
NM_143540.2 → NP_651797.1 ceramidase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YTD8, Q86NP1, Q9VA70

UniProtKB/TrEMBL

A4V3N7

Related

FBpp0085008

Conserved Domains (3) summary

PTZ00487
Location:24 → 701

PTZ00487; ceramidase; Provisional

pfam04734
Location:25 → 538

Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal

pfam17048
Location:540 → 701

Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal