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    CG3808 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3808provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036838
    Locus tag
    Dmel_CG3808
    See related
    AllianceGenome:FB:FBgn0036838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3808; Dmel\CG3808
    Summary
    Predicted to enable mRNA binding activity and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Predicted to be involved in RNA processing. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; longitudinal visceral muscle primordium; and trunk mesoderm. Orthologous to human TRMT2A (tRNA methyltransferase 2 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3808 in Genome Data Viewer
    Location:
    75F2-75F2; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18997875..19000608, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18990975..18993708, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 2 Neighboring gene naked cuticle Neighboring gene long non-coding RNA:CR45940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A. Witzenberger M, et al. Acta Crystallogr F Struct Biol Commun, 2024 Feb 1. PMID 38270511, Free PMC Article
    2. Regulation of the feedback antagonist naked cuticle by Wingless signaling. Chang JL, et al. Dev Biol, 2008 Sep 15. PMID 18585374, Free PMC Article
    3. Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. Maurer GW, et al. PLoS Genet, 2020 Apr. PMID 32339168, Free PMC Article
    4. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. VoSSfeldt H, et al. PLoS One, 2012. PMID 23139745, Free PMC Article
    5. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Butzlaff M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25794683

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3808-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18997875..19000608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140826.2 → NP_649083.2  uncharacterized protein Dmel_CG3808 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649083.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R49, Q9VVV7
      Related
      FBpp0074808, FBtr0075041
      Conserved Domains (3) summary
      COG2265
      Location:57 → 571
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:56 → 134
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins
      cl17173
      Location:276 → 579
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R49 Q95R49
    Q9VVV7 Q9VVV7

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