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    RIOK1 RIO kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIOK1provided by FlyBase
    Official Full Name
    RIO kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036187
    Locus tag
    Dmel_CG11660
    See related
    AllianceGenome:FB:FBgn0036187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11660; Dmel\CG11660; dRIOK1; Rio1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of glial cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Orthologous to human RIOK1 (RIO kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RIOK1 in Genome Data Viewer
    Location:
    68D1-68D1; 3-36 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11646234..11648474, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11639334..11641574, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45158 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit H Neighboring gene uncharacterized protein Neighboring gene mir-274 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency. Nithianandam V, et al. Hum Mol Genet, 2024 May 4. PMID 38324746, Free PMC Article
    2. Classification and functional annotation of eukaryotic protein kinases. Miranda-Saavedra D, et al. Proteins, 2007 Sep 1. PMID 17557329
    3. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. Read RD, et al. PLoS Genet, 2013. PMID 23459592, Free PMC Article
    4. Drosophila melanogaster as a Model System for Human Glioblastomas. Chen AS, et al. Adv Exp Med Biol, 2019. PMID 31520357
    5. p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion. Hasygar K, et al. PLoS Genet, 2014 Nov. PMID 25393288, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RIO kinase 1
    Names
    CG11660-PA
    CG11660-PB
    RIOK1-PA
    RIOK1-PB
    NP_648489.1
    NP_729730.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11646234..11648474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140232.3 → NP_648489.1  RIO kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTL5
      Related
      FBpp0075865
      Conserved Domains (2) summary
      COG1718
      Location:164 → 420
      RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
      cd05147
      Location:205 → 395
      RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase

    2. NM_168469.2 → NP_729730.1  RIO kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTL5
      Related
      FBpp0075866
      Conserved Domains (2) summary
      COG1718
      Location:164 → 420
      RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
      cd05147
      Location:205 → 395
      RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTL5 Q9VTL5

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