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    dib disembodied [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45282, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dibprovided by FlyBase
    Official Full Name
    disembodiedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000449
    Locus tag
    Dmel_CG12028
    See related
    AllianceGenome:FB:FBgn0000449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    302a1; CG12028; Cyp; Cyp27; Cyp302a1; CYP302A1; Dib; Dmel\CG12028; l(3)64Ak; l(3)dib; l(3)SH14
    Summary
    Enables ecdysteroid 22-hydroxylase activity. Involved in several processes, including chitin-based embryonic cuticle biosynthetic process; ecdysone biosynthetic process; and embryonic development via the syncytial blastoderm. Located in mitochondrion. Is expressed in several structures, including embryonic epidermis; follicle cell; prothoracic gland; prothoracic segment; and ring gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dib in Genome Data Viewer
    Location:
    64A5-64A5; 3-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4062292..4064551)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4062292..4064551)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dpy-30-like 2 Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 305 member A1 Neighboring gene wishful thinking Neighboring gene uncharacterized protein Neighboring gene Fumarylacetoacetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster. Warren JT, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12177427, Free PMC Article
    2. CYP18A1, a key enzyme of Drosophila steroid hormone inactivation, is essential for metamorphosis. Guittard E, et al. Dev Biol, 2011 Jan 1. PMID 20932968
    3. Distinct nutritional and endocrine regulation of prothoracic gland activities underlies divergent life history strategies in Manduca sexta and Drosophila melanogaster. Xu LC, et al. Insect Biochem Mol Biol, 2020 Apr. PMID 32061770
    4. Discrete pulses of molting hormone, 20-hydroxyecdysone, during late larval development of Drosophila melanogaster: correlations with changes in gene activity. Warren JT, et al. Dev Dyn, 2006 Feb. PMID 16273522, Free PMC Article
    5. Enhanced sensitivity of midline glial cells to apoptosis is achieved by HOW(L)-dependent repression of Diap1. Reuveny A, et al. Mech Dev, 2009 Jan-Feb. PMID 18984040

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. codes for a mitochondrial cytochrome P450 that mediates the last two hydroxylation reactions in the ecdysteroidogenic pathway in Drosophila
      Title: Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ecdysteroid 22-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ecdysone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disembodied
    Names
    CG12028-PA
    cytochrome P450
    dib-PA
    NP_524810.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4062292..4064551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080071.3 → NP_524810.2  disembodied [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524810.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q059D3, Q9NGX9, Q9VZJ0
      Related
      FBpp0073061
      Conserved Domains (1) summary
      cl12078
      Location:25 → 446
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NGX9.2 Q9NGX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools