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    acj6 abnormal chemosensory jump 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acj6provided by FlyBase
    Official Full Name
    abnormal chemosensory jump 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0000028
    Locus tag
    Dmel_CG9151
    See related
    AllianceGenome:FB:FBgn0000028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acj6; ACJ6; CG9151; Dmel\CG9151; I-POU; Ipou; tI-POU
    Summary
    Enables DNA-binding transcription factor activity and transcription corepressor activity. Involved in several processes, including chemosensory jump behavior; detection of chemical stimulus involved in sensory perception of smell; and neuron development. Predicted to be located in nucleus. Is expressed in several structures, including adult central complex; adult optic lobe; central brain primordium; ganglia; and neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 15. Orthologous to several human genes including POU4F2 (POU class 4 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See acj6 in Genome Data Viewer
    Location:
    13B8-13C1; 1-50 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15350239..15379064, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15244272..15273097, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 5 Neighboring gene Protein phosphatase 1 at 13C Neighboring gene uncharacterized protein Neighboring gene Cyclic nucleotide-gated ion channel-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Olfactory physiology in the Drosophila antenna and maxillary palp: acj6 distinguishes two classes of odorant pathways. Ayer RK Jr, et al. J Neurobiol, 1992 Oct. PMID 1460467
    2. acj6: a gene affecting olfactory physiology and behavior in Drosophila. Ayer RK Jr, et al. Proc Natl Acad Sci U S A, 1991 Jun 15. PMID 1905022, Free PMC Article
    3. Molecular genetics of Drosophila olfaction. Carlson J. Ciba Found Symp, 1993. PMID 8168375
    4. A complete developmental sequence of a Drosophila neuronal lineage as revealed by twin-spot MARCM. Yu HH, et al. PLoS Biol, 2010 Aug 24. PMID 20808769, Free PMC Article
    5. Olfaction. Good reception in fruitfly antennae. Pilpel Y, et al. Nature, 1999 Mar 25. PMID 10192327

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brn3/POU-IV-type POU homeobox genes-Paradigmatic regulators of neuronal identity across phylogeny.
      Title: Brn3/POU-IV-type POU homeobox genes-Paradigmatic regulators of neuronal identity across phylogeny.
    2. Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
      Title: Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.
    3. To analyze transcription factors involved in gene regulation by testis-specific TAF (tTAF), tTAF-dependent promoters were mapped and analyzed in silico. Core promoters show decreased AT content and enrichment with translation control element CAAAATTY. Transcriptome study of testes from male mutants for tTAF, Acj6, and Modulo implies the existence of a regulatory hierarchy of tTAF, Modulo and Acj6.
      Title: Evidence for a hierarchical transcriptional circuit in Drosophila male germline involving testis-specific TAF and two gene-specific transcription factors, Mod and Acj6.
    4. Late expression of some acj6 splice forms is sufficient to rescue some odor receptor neuron classes, consistent with a direct role for Acj6 isoforms in receptor gene expression; individual splice forms are able to act both positively and negatively.
      Title: Distinct functions of acj6 splice forms in odor receptor gene choice.
    5. Acj6 acts directly in the process of receptor gene choice; it plays a dual role, positive and negative, in the logic of the process, and acts in partitioning the larval and adult receptor repertoires.
      Title: Positive and negative regulation of odor receptor gene choice in Drosophila by acj6.
    6. From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons.
      Title: From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemosensory jump behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    abnormal chemosensory jump 6
    Names
    CG9151-PA
    CG9151-PC
    CG9151-PD
    CG9151-PE
    CG9151-PF
    CG9151-PG
    CG9151-PH
    CG9151-PI
    CG9151-PJ
    CG9151-PK
    CG9151-PL
    CG9151-PM
    CG9151-PN
    abnormal chemosensory jumb
    acj6-PA
    acj6-PC
    acj6-PD
    acj6-PE
    acj6-PF
    acj6-PG
    acj6-PH
    acj6-PI
    acj6-PJ
    acj6-PK
    acj6-PL
    acj6-PM
    acj6-PN
    altered chemosensory jump 6
    twin of I-POU

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15350239..15379064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258755.2 → NP_001245684.1  abnormal chemosensory jump 6, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDX7, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:192 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:293 → 347
      Homeobox; Homeobox domain

    2. NM_001014743.3 → NP_001014743.1  abnormal chemosensory jump 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:222 → 299
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:321 → 375
      Homeobox; Homeobox domain

    3. NM_001258754.2 → NP_001245683.1  abnormal chemosensory jump 6, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NH29, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:185 → 262
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284 → 338
      Homeobox; Homeobox domain

    4. NM_001258756.2 → NP_001245685.1  abnormal chemosensory jump 6, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGG0, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:185 → 262
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:286 → 340
      Homeobox; Homeobox domain

    5. NM_001144726.2 → NP_001138198.1  abnormal chemosensory jump 6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Y6, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:192 → 269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:291 → 345
      Homeobox; Homeobox domain

    6. NM_001258758.2 → NP_001245687.1  abnormal chemosensory jump 6, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245687.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF66, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:204 → 281
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:303 → 357
      Homeobox; Homeobox domain

    7. NM_001258760.2 → NP_001245689.1  abnormal chemosensory jump 6, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDY0, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:204 → 281
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:305 → 359
      Homeobox; Homeobox domain

    8. NM_001258759.2 → NP_001245688.1  abnormal chemosensory jump 6, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NH32, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:211 → 288
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:310 → 364
      Homeobox; Homeobox domain

    9. NM_001014744.2 → NP_001014744.1  abnormal chemosensory jump 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:196 → 273
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:295 → 349
      Homeobox; Homeobox domain

    10. NM_001258757.2 → NP_001245686.1  abnormal chemosensory jump 6, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEH8, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:196 → 273
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:297 → 351
      Homeobox; Homeobox domain

    11. NM_167438.2 → NP_727845.1  abnormal chemosensory jump 6, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGS2
      Related
      FBpp0288502
      Conserved Domains (2) summary
      smart00352
      Location:203 → 280
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:302 → 356
      Homeobox; Homeobox domain

    12. NM_001258753.2 → NP_001245682.1  abnormal chemosensory jump 6, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245682.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF61, Q0IGS2
      Conserved Domains (2) summary
      smart00352
      Location:215 → 292
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:314 → 368
      Homeobox; Homeobox domain

    13. NM_080137.3 → NP_524876.1  abnormal chemosensory jump 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77214, P24350, Q26465, Q59E44, Q59E45, Q8IR36, Q9VXW1
      UniProtKB/TrEMBL
      Q0IGS2
      Related
      FBpp0073832
      Conserved Domains (2) summary
      smart00352
      Location:222 → 299
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:323 → 377
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0Y6 B7Z0Y6
    M9NDX7 M9NDX7
    M9NDY0 M9NDY0
    M9NEH8 M9NEH8
    M9NF61 M9NF61
    M9NF66 M9NF66
    M9NGG0 M9NGG0
    M9NH29 M9NH29
    M9NH32 M9NH32
    P24350.3 P24350

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