Mulk Multi-substrate lipid kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mulkprovided by FlyBase
Official Full Name: Multi-substrate lipid kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0260750
Locus tag: Dmel_CG31873
See related: AllianceGenome:FB:FBgn0260750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-31BCb; CG18162; CG31873; Dmel\CG31873; Dmulk
Summary: Enables ceramide kinase activity. Involved in ceramide metabolic process; germ cell migration; and lipid phosphorylation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and larval muscle system. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10270051..10271465)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10270051..10271465)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-erythro-sphingosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_723549.1

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The following sections contain reference sequences that belong to a specific genome build. Explain