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    Nprl3 Nitrogen permease regulator-like 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nprl3provided by FlyBase
    Official Full Name
    Nitrogen permease regulator-like 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036397
    Locus tag
    Dmel_CG8783
    See related
    AllianceGenome:FB:FBgn0036397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8783; Dmel\CG8783; GATOR1; Nplr3; NPR3; nprl3
    Summary
    Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and negative regulation of cell size. Located in autolysosome and nucleus. Part of GATOR2 complex. Is expressed in organism. Used to study familial focal epilepsy with variable foci 3. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nprl3 in Genome Data Viewer
    Location:
    70C11-70C11; 3-41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13999380..14001880, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13992480..13994980, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cathepsin K1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene upSET Neighboring gene PAX transcription activation domain interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity. Cheng Y, et al. Biol Open, 2020 Nov 6. PMID 33037015, Free PMC Article
    2. Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy. Du S, et al. Sci China Life Sci, 2023 Sep. PMID 37071290
    3. The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Wei Y, et al. Cell Death Differ, 2014 Sep. PMID 24786828, Free PMC Article
    4. The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster. Wei Y, et al. G3 (Bethesda), 2016 Dec 7. PMID 27672113, Free PMC Article
    5. TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. Wei Y, et al. Proc Natl Acad Sci U S A, 2014 Dec 30. PMID 25512509, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy.
      Title: Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy.
    2. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
      Title: FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of triglyceride catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GATOR1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GATOR1 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of GATOR2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nitrogen permease regulator-like 3
    Names
    CG8783-PA
    CG8783-PB
    CG8783-PC
    Nprl3-PA
    Nprl3-PB
    Nprl3-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13999380..14001880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168570.1 → NP_729945.1  nitrogen permease regulator-like 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1X9, Q95RI3, Q9VUB4
      UniProtKB/TrEMBL
      B6IDY8
      Related
      FBpp0075527, FBtr0075785
      Conserved Domains (1) summary
      cl24021
      Location:76 → 413
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    2. NM_140423.3 → NP_648680.2  nitrogen permease regulator-like 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648680.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1X9, Q95RI3, Q9VUB4
      UniProtKB/TrEMBL
      B6IDY8
      Related
      FBpp0075528
      Conserved Domains (1) summary
      cl24021
      Location:76 → 413
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3

    3. NM_001274889.1 → NP_001261818.1  nitrogen permease regulator-like 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1X9, Q95RI3, Q9VUB4
      UniProtKB/TrEMBL
      B6IDY8
      Conserved Domains (1) summary
      cl24021
      Location:76 → 413
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6IDY8 B6IDY8
    Q9VUB4.1 Q9VUB4

    Gene LinkOut

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