Prosalpha6 Proteasome alpha6 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosalpha6provided by FlyBase
Official Full Name: Proteasome alpha6 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0250843
Locus tag: Dmel_CG4904
See related: AllianceGenome:FB:FBgn0250843
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 143314_at; alpha-6; Alpha-6; alpha6; alpha_dm; anon-SAGE:Wang-116; CG4904; Dmel\CG4904; pros 35; Pros alpha6; Pros-35; PROS-35; Pros-Dm35; PROS-Dm35; pros35; Pros35; PSMA1
Summary: Involved in ventral furrow formation. Acts upstream of with a positive effect on determination of adult lifespan. Located in cytoplasm and nucleus. Part of proteasome complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; gut section; and mesoderm. Orthologous to human PSMA1 (proteasome 20S subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10221351..10222546)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10221351..10222546)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Proteasome alpha6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.
Title: Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

Names: 20S alpha6 subunit; 20s proteasome; CG4904-PA; CG4904-PB; Prosalpha6-PA; Prosalpha6-PB; alpha-subunit of 20S proteasome; alpha6; anon-SAGE:Wang-116; proteasome 35; proteasome 35 kD subunit; proteasome 35-kDa subunit; proteasome 35kD subunit; proteasome 35kDa subunit

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