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    lov jim lovell [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38007, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lovprovided by FlyBase
    Official Full Name
    jim lovellprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266129
    Locus tag
    Dmel_CG16778
    See related
    AllianceGenome:FB:FBgn0266129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    091y; 91Y; anon-G2; BTB-III; BtbIII; CG16778; CG2672; Dmel\CG16778; dTKR; g2; Lov; tkr; Tkr; TKR
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including larval feeding behavior; larval walking behavior; and negative gravitaxis. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; head epidermis primordium; midline neuroblast of ventral nervous system; and unpaired neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lov in Genome Data Viewer
    Location:
    60F3-60F5; 2-107 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25085780..25139627, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20973303..21027150, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Alanine-CGC 1-2 Neighboring gene transfer RNA:Alanine-CGC 1-3 Neighboring gene goliath Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Seminal fluid protein 60F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dorsal and neural expression of a tyrosine kinase-related Drosophila gene during embryonic development. Haller J, et al. Genes Dev, 1987 Oct. PMID 3428600
    2. The Drosophila BTB domain protein Jim Lovell has roles in multiple larval and adult behaviors. Bjorum SM, et al. PLoS One, 2013. PMID 23620738, Free PMC Article
    3. Phenotypic association of spontaneous ovulation and sexual receptivity in virgin females of Drosophila melanogaster mutants. Ejima A, et al. Behav Genet, 2001 Sep. PMID 11777172
    4. Failure to Burrow and Tunnel Reveals Roles for jim lovell in the Growth and Endoreplication of the Drosophila Larval Tracheae. Zhou F, et al. PLoS One, 2016. PMID 27494251, Free PMC Article
    5. The roles of jim lovell and uninflatable in different endopolyploid larval tissues of Drosophila melanogaster. Zhou F, et al. PLoS One, 2020. PMID 32822370, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The roles of jim lovell and uninflatable in different endopolyploid larval tissues of Drosophila melanogaster.
      Title: The roles of jim lovell and uninflatable in different endopolyploid larval tissues of Drosophila melanogaster.
    2. Lov is necessary for tracheal endoreplicative growth and that its loss in this tissue causes loss of tracheal integrity resulting in chronic hypoxia and abnormal burrowing and tunneling behavior.
      Title: Failure to Burrow and Tunnel Reveals Roles for jim lovell in the Growth and Endoreplication of the Drosophila Larval Tracheae.
    3. Transcript and protein expression patterns have been examined and behavioral phenotypes of new lov mutations have been characterized.
      Title: The Drosophila BTB domain protein Jim Lovell has roles in multiple larval and adult behaviors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c25089627-25088943 mobile_element_type = transposon:INE-1{}3359
    • Loc: c25107283-25107107 mobile_element_type = transposon:INE-1{}3362

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventral midline development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jim lovell
    Names
    91Y
    BTB-protein-III
    CG16778-PB
    CG16778-PC
    CG16778-PD
    CG16778-PE
    CG16778-PF
    Jim lovell
    lov-PB
    lov-PC
    lov-PD
    lov-PE
    lov-PF
    tyrosine kinase related
    tyrosine kinase-related
    tyrosine kinase-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      25085780..25139627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079141.4 → NP_523865.2  jim lovell, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523865.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZV7, P14083, Q0E8V9, Q24002, Q7JPM0, Q7KA34, Q9U1H2, Q9W0W2
      UniProtKB/TrEMBL
      A0A0B4LGK1
      Related
      FBpp0072359
      Conserved Domains (3) summary
      smart00225
      Location:141 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:130 → 225
      BTB; BTB/POZ domain
      pfam05225
      Location:791 → 834
      HTH_psq; helix-turn-helix, Psq domain

    2. NM_001014554.3 → NP_001014554.1  jim lovell, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014554.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZV7, P14083, Q0E8V9, Q24002, Q7JPM0, Q7KA34, Q9U1H2, Q9W0W2
      UniProtKB/TrEMBL
      A0A0B4LGK1
      Conserved Domains (3) summary
      smart00225
      Location:141 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:130 → 225
      BTB; BTB/POZ domain
      pfam05225
      Location:791 → 834
      HTH_psq; helix-turn-helix, Psq domain

    3. NM_145761.2 → NP_665704.1  jim lovell, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_665704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZV7, P14083, Q0E8V9, Q24002, Q7JPM0, Q7KA34, Q9U1H2, Q9W0W2
      UniProtKB/TrEMBL
      A0A0B4LGK1
      Related
      FBpp0072360
      Conserved Domains (3) summary
      smart00225
      Location:141 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:130 → 225
      BTB; BTB/POZ domain
      pfam05225
      Location:791 → 834
      HTH_psq; helix-turn-helix, Psq domain

    4. NM_001299947.1 → NP_001286876.1  jim lovell, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZV7, P14083, Q0E8V9, Q24002, Q7JPM0, Q7KA34, Q9U1H2, Q9W0W2
      UniProtKB/TrEMBL
      A0A0B4LGK1
      Conserved Domains (3) summary
      smart00225
      Location:141 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:130 → 225
      BTB; BTB/POZ domain
      pfam05225
      Location:791 → 834
      HTH_psq; helix-turn-helix, Psq domain

    5. NM_138150.4 → NP_611994.3  jim lovell, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611994.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P14083
      Conserved Domains (3) summary
      smart00225
      Location:141 → 226
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:130 → 225
      BTB; BTB/POZ domain
      pfam05225
      Location:791 → 834
      HTH_psq; helix-turn-helix, Psq domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGK1 A0A0B4LGK1
    P14083.2 P14083

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