oc ocelliless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ocprovided by FlyBase
Official Full Name: ocellilessprovided by FlyBase
Primary source: FLYBASE:FBgn0004102
Locus tag: Dmel_CG12154
See related: AllianceGenome:FB:FBgn0004102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12154; Dmel\CG12154; l(1)7Ff; l(1)8Ac; Oc; OC; oc2; ort; orthodenticle; otd; Otd; Otx; uvi
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including nervous system development; positive regulation of compound eye photoreceptor development; and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; brain; head epidermis primordium; and photoreceptor neurons. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to several human genes including OTX1 (orthodenticle homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7F10-8A1; 1-23 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8630159..8650681, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8524192..8544714, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results indicate that the head-specific gap gene empty spiracles can act as a repressor of Toy, while ocelliless (oc) and spalt major (salm) appear to act as positive regulators of toy gene expression
Title: Regulation of twin of eyeless during Drosophila development.
Otd is a main component of the gene regulatory network that regulates synaptic-column and layer targeting in the fly visual system.
Title: Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina.
The conserved homeobox protein Orthodenticle acts together with the ecdysone receptor to directly repress the expression of Kruppel homolog 1.
Title: Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation.
Orthodenticle is expressed in a group of clonally related dopamine neurons from first instar larvae to adulthood, making it possible to establish an identity relationship between larval and adult dopamine neuron clusters.
Title: Orthodenticle is necessary for survival of a cluster of clonally related dopaminergic neurons in the Drosophila larval and adult brain.
Sequence analysis indicates that many of the transcriptional regulatory domains identified here are conserved in multiple Diptera Otd-related proteins.
Title: Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events.
Although Otd and Pph13 have been implicated in rhabdomere morphogenesis, we demonstrate that it is necessary to remove both factors to completely eliminate rhabdomere formation.
Title: Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function.
Data show that otd/Otx gene is involved in the specification of the anterior brain during embryonic CNS development in Drosophila.
Title: Anteroposterior regionalization of the brain: genetic and comparative aspects.
Otd as a critical regulator of photoreceptor morphology and phototransduction
Title: Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates.
Otd is a key player in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin expression
Title: Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina.
Mutational inactivation of otd/Otx2 and unpg/Gbx2 result in the loss or misplacement of the brain-specific expression domains of Pax2/5/8 and Hox genes.
Title: An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult walking behavior	TAS Traceable Author Statement more info	PubMed
involved_in anterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in anterior region determination	TAS Traceable Author Statement more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	TAS Traceable Author Statement more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in ocellus development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ocellus morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in ocellus photoreceptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pattern specification process	NAS Non-traceable Author Statement more info	PubMed
involved_in photoreceptor cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: ocelliless

Names: CG12154-PC; CG12154-PD; CG12154-PE; CG12154-PF; CG12154-PG; CG12154-PH; oc-PC; oc-PD; oc-PE; oc-PF; oc-PG; oc-PH; orthodentical; orthodenticle; uvi-insensitive