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    yl yolkless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32367, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ylprovided by FlyBase
    Official Full Name
    yolklessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004649
    Locus tag
    Dmel_CG1372
    See related
    AllianceGenome:FB:FBgn0004649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1372; CT3114; Dmel\CG1372; DmYPR; fs(1)148; fs(1)5; fs(1)A148; fs(1)K184; fs(1)L186; fs(1)L193; fs(1)L196; fs(1)L211; fs(1)M205; fs(1)M25; fs(1)yl; fs(1)yolkless; LR13; Yl; YL; yokeless
    Summary
    Predicted to enable vitellogenin receptor activity. Located in coated vesicle. Is expressed in adult head; organism; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    12E3-12E3; 1-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14193214..14199958)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14087247..14093991)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-4917 stem loop Neighboring gene uncharacterized protein Neighboring gene pre-mRNA processing factor 16 Neighboring gene lethal (1) G0469

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Female sterile (1) yolkless: a recessive female sterile mutation in Drosophila melanogaster with depressed numbers of coated pits and coated vesicles within the developing oocytes. DiMario PJ, et al. J Cell Biol, 1987 Jul. PMID 2886508, Free PMC Article
    2. Ligand-binding domains in vitellogenin receptors and other LDL-receptor family members share a common ancestral ordering of cysteine-rich repeats. Sappington TW, et al. J Mol Evol, 1998 Apr. PMID 9541543
    3. Isolation of germ line-dependent female-sterile mutation that affects yolk specific sequestration and chorion formation in Drosophila. Waring GL, et al. Dev Biol, 1983 Dec. PMID 6418588
    4. Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery. Herren JK, et al. mBio, 2013 Mar 5. PMID 23462112, Free PMC Article
    5. The Drosophila yolkless gene encodes a vitellogenin receptor belonging to the low density lipoprotein receptor superfamily. Schonbaum CP, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878005, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitellogenin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    yolkless
    Names
    CG1372-PA
    CG1372-PB
    Dm yolkless
    YP receptor
    yl-PA
    yl-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14193214..14199958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078596.3 → NP_511151.2  yolkless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511151.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0D4RRS9
      Related
      FBpp0073714
      Conserved Domains (6) summary
      smart00192
      Location:1340 → 1371
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:553 → 595
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:1418 → 1452
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:1158 → 1191
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:529 → 569
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:352 → 387
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. NM_206710.2 → NP_996433.1  yolkless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P98163, Q86P52, Q9VY56
      Conserved Domains (6) summary
      smart00192
      Location:1157 → 1189
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:553 → 595
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:1418 → 1452
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:1283 → 1318
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:529 → 569
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:352 → 387
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98163.2 P98163

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