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    slbo slow border cells [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slboprovided by FlyBase
    Official Full Name
    slow border cellsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005638
    Locus tag
    Dmel_CG4354
    See related
    AllianceGenome:FB:FBgn0005638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C/EBP; CG4354; DC/EBP; Dm-c/EBP; DM8; DmC/EBP; Dmel\CG4354; fs(2)7; fs(2)8; fs(2)ry7; fs(2)ry8; Slbo; SLBO; slobo
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in border follicle cell migration; positive regulation of border follicle cell migration; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic head epidermis; epidermis; follicle cell; gut section; and nephrocyte. Human ortholog(s) of this gene implicated in acute myeloid leukemia and primary immunodeficiency disease. Orthologous to several human genes including CEBPA (CCAAT enhancer binding protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slbo in Genome Data Viewer
    Location:
    60C6-60C6; 2-106 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24331522..24334307, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20219045..20221830, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 60D Neighboring gene long non-coding RNA:CR44810 Neighboring gene long non-coding RNA:CR44282 Neighboring gene blistered Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development. Rørth P, et al. Genes Dev, 1992 Dec. PMID 1459454
    2. Migration on the borderline. Greaves S. Nat Cell Biol, 2001 Feb. PMID 11175759
    3. An enhancer region within the copia untranslated leader contains binding sites for Drosophila regulatory proteins. Wilson S, et al. Gene, 1998 Mar 16. PMID 9524274
    4. The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system. Guillemin K, et al. Development, 1996 May. PMID 8625824
    5. GAGA Regulates Border Cell Migration in Drosophila. Ogienko AA, et al. Int J Mol Sci, 2020 Oct 10. PMID 33050455, Free PMC Article

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data conclude that the regulatory feedback loop between Tj and Slbo is necessary for achieving the correct activity levels of migration-regulating factors to ensure proper BCC motility.
      Title: The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.
    2. downregulated in delaminating epithelia as expression of Slbo is upregulated; this expression pattern during cell migration is achieved by negative feedback - slbo represses Trbl expression and trbl is necessary and sufficient to promote Slbo protein turnover
      Title: The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cell migration.
    3. Opposing interactions between Drosophila cut and the C/EBP encoded by slow border cells direct apical constriction and epithelial invagination
      Title: Opposing interactions between Drosophila cut and the C/EBP encoded by slow border cells direct apical constriction and epithelial invagination.
    4. In anterior follicle cells exposed to a Dpp morphogen gradient, high and low levels of slbo and bun, respectively, are established by modulation of Notch signaling to direct threshold cell fates.
      Title: Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration.
    5. The slbo protein, a C/EBP family transcriptional activator, is required for Border cells to become migratory.
      Title: Systematic analysis of the transcriptional switch inducing migration of border cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    slow border cells
    Names
    CCAAT/enhancer binding protein
    CG4354-PA
    CG4354-PB
    slbo-PA
    slbo-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24331522..24334307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079119.3 → NP_523843.1  slow border cells, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02637, Q9W183
      UniProtKB/TrEMBL
      A0A0B4LGG2
      Related
      FBpp0072179
      Conserved Domains (1) summary
      cd14693
      Location:362 → 420
      bZIP_CEBP; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein (CEBP) and similar proteins: a DNA-binding and dimerization domain

    2. NM_001299907.1 → NP_001286836.1  slow border cells, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286836.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02637, Q9W183
      UniProtKB/TrEMBL
      A0A0B4LGG2
      Conserved Domains (1) summary
      cd14693
      Location:362 → 420
      bZIP_CEBP; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein (CEBP) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGG2 A0A0B4LGG2
    Q02637.3 Q02637

    Gene LinkOut

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