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    hep hemipterous [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hepprovided by FlyBase
    Official Full Name
    hemipterousprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010303
    Locus tag
    Dmel_CG4353
    See related
    AllianceGenome:FB:FBgn0010303
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2190; CG4353; D-MKK7; DHEP/MKK7; dJNKK; DJNKK; Dmel\CG4353; dMKK7; DMKK7; hem; Hep; HEP; hep/JNKK; Hep/Mkk7; HEP/MKK7; hp; hrp; Jnkk; JNKK; l(1)7P1; l(1)G0107; l(1)G0208; MAP2K7; MAPKK; Mkk7; MKK7
    Summary
    Enables JUN kinase kinase activity; MAP-kinase scaffold activity; and protein kinase binding activity. Involved in several processes, including defense response to other organism; imaginal disc morphogenesis; and positive regulation of cellular component biogenesis. Located in axon. Is expressed in adult antennal lobe; adult brain; adult mushroom body; and organism. Used to study heart disease. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hep in Genome Data Viewer
    Location:
    11D10-11D10; 1-41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13079205..13090434, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12973238..12984467, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene radish Neighboring gene antisense RNA:CR44840 Neighboring gene uncharacterized protein Neighboring gene mir-971 stem loop Neighboring gene uncharacterized protein Neighboring gene licorne Neighboring gene Chondroitin polymerizing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease. Hong YK, et al. J Ethnopharmacol, 2011 Apr 12. PMID 21333721
    2. Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila. Branco AT, et al. Heredity (Edinb), 2017 Mar. PMID 27731328, Free PMC Article
    3. In Vivo Screening of Traditional Medicinal Plants for Neuroprotective Activity against Aβ42 Cytotoxicity by Using Drosophila Models of Alzheimer's Disease. Liu QF, et al. Biol Pharm Bull, 2015. PMID 26458335
    4. Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase. Karkali K, et al. Int J Mol Sci, 2021 Nov 11. PMID 34830088, Free PMC Article
    5. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. Lee MJ, et al. Mol Cells, 2011 Apr. PMID 21331775, Free PMC Article

    See all (545) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in Drosophila both MAPKKs, Hep/Mkk7 and Mkk4, are required to induce JNK upon TNF or pro-inflammatory stimulation
      Title: A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.
    2. Apoptotic cells can induce compensatory cell proliferation through the JNKK signaling pathway.
      Title: Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables MAP-kinase scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in basement membrane disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorion micropyle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorion-containing eggshell pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, spreading of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc eversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc fusion, thorax closure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intestinal stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidoglycan recognition protein signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of border follicle cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hemipterous
    Names
    CG4353-PA
    CG4353-PC
    CG4353-PD
    CG4353-PE
    CG4353-PF
    CG4353-PG
    CG4353-PH
    JNK kinase
    JNK-Kinase
    Mitogen-activated protein kinase kinase 7
    hemipterus
    hempiterous
    hep-PA
    hep-PC
    hep-PD
    hep-PE
    hep-PF
    hep-PG
    hep-PH
    NP_001259500.1
    NP_001259501.1
    NP_001285182.1
    NP_001368981.1
    NP_001368982.1
    NP_511142.2
    NP_727661.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13079205..13090434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298253.1 → NP_001285182.1  hemipterous, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285182.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JJV1
      Conserved Domains (2) summary
      smart00220
      Location:203 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

    2. NM_001272571.2 → NP_001259500.1  hemipterous, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEF9
      Conserved Domains (2) summary
      smart00220
      Location:203 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

    3. NM_001382110.1 → NP_001368981.1  hemipterous, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EF36
      Conserved Domains (1) summary
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

    4. NM_001382111.1 → NP_001368982.1  hemipterous, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEQ6
      Conserved Domains (1) summary
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

    5. NM_167346.2 → NP_727661.1  hemipterous, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18411, Q23977, Q8SZ04, Q8SZZ1, Q9I7S3
      Related
      FBpp0073578
      Conserved Domains (2) summary
      smart00220
      Location:203 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

    6. NM_001272572.2 → NP_001259501.1  hemipterous, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH06
      Conserved Domains (2) summary
      smart00220
      Location:203 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

    7. NM_078587.3 → NP_511142.2  hemipterous, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511142.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH06
      Related
      FBpp0073579
      Conserved Domains (2) summary
      smart00220
      Location:203 → 456
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06618
      Location:181 → 476
      PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EEQ6 A0A6H2EEQ6
    A0A6H2EF36 A0A6H2EF36
    M9PEF9 M9PEF9
    M9PH06 M9PH06
    Q23977.2 Q23977
    X2JJV1 X2JJV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools