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    Ts Thymidylate synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33499, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tsprovided by FlyBase
    Official Full Name
    Thymidylate synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024920
    Locus tag
    Dmel_CG3181
    See related
    AllianceGenome:FB:FBgn0024920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-23Ca; c1.5; CG3181; Dmel\CG3181; FBgn0024920; TS
    Summary
    Predicted to enable thymidylate synthase activity. Predicted to be involved in dTMP biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; digenic dyskeratosis congenita; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    23C3-23C3; 2-8 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2968293..2969638, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2968293..2969638, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene NTPase Neighboring gene lilliputian Neighboring gene RNA-binding protein 9 Neighboring gene gamma-Tubulin at 23C Neighboring gene Recombination repair protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila. Pilesi E, et al. J Cell Physiol, 2023 Jul. PMID 37183313
    2. Serine hydroxymethyl transferase is required for optic lobe neuroepithelia development in Drosophila. Silva EAB, et al. Development, 2023 Oct 15. PMID 36896963, Free PMC Article
    3. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    4. Two distinct waves of transcriptome and translatome changes drive Drosophila germline stem cell differentiation. Samuels TJ, et al. EMBO J, 2024 Apr. PMID 38480936, Free PMC Article
    5. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables thymidylate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidylate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thymidylate synthase
    Names
    CG3181-PA
    CG3181-PB
    Ts-PA
    Ts-PB
    thymidilate synthetase
    NP_001285570.1
    NP_477367.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2968293..2969638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058019.4 → NP_477367.1  thymidylate synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76511, Q9VQJ3
      UniProtKB/TrEMBL
      Q541C9
      Related
      FBpp0077363
      Conserved Domains (1) summary
      pfam00303
      Location:39 → 321
      Thymidylat_synt; Thymidylate synthase

    2. NM_001298641.1 → NP_001285570.1  thymidylate synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76511, Q9VQJ3
      UniProtKB/TrEMBL
      Q541C9
      Conserved Domains (1) summary
      pfam00303
      Location:39 → 321
      Thymidylat_synt; Thymidylate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76511.2 O76511
    Q541C9 Q541C9

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