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    Drep3 DNA fragmentation factor-related protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drep3provided by FlyBase
    Official Full Name
    DNA fragmentation factor-related protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028407
    Locus tag
    Dmel_CG8364
    See related
    AllianceGenome:FB:FBgn0028407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT08574; CG13187; CG8364; Dmel\CG8364; drep-3; Drep-3; DREP-3; drep3; DREP3; Rep3
    Summary
    Predicted to be involved in regulation of apoptotic process. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5 and obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a); CIDEB (cell death inducing DFFA like effector b); and CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Drep3 in Genome Data Viewer
    Location:
    48D8-48D8; 2-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12055089..12062866)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7942594..7950371)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor-related protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Helical filament structure of the DREP3 CIDE domain reveals a unified mechanism of CIDE-domain assembly. Lee SY, et al. Acta Crystallogr D Struct Biol, 2021 Dec 1. PMID 34866610, Free PMC Article
    2. Crystallization and preliminary X-ray crystallographic studies of the CIDE-domain complex between Drep2 and Drep3 from Drosophila melanogaster. Park OK, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Apr 1. PMID 21505240, Free PMC Article
    3. Molecular basis of apoptotic DNA fragmentation by DFF40. Ha HJ, et al. Cell Death Dis, 2022 Mar 2. PMID 35236824, Free PMC Article
    4. Genes with homology to DFF/CIDEs found in Drosophila melanogaster. Inohara N, et al. Cell Death Differ, 1999 Sep. PMID 10627165
    5. Dual apoptotic DNA fragmentation system in the fly: Drep2 is a novel nuclease of which activity is inhibited by Drep3. Park OK, et al. FEBS Lett, 2012 Sep 21. PMID 22850116

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the basic surface side of Drep2 CIDE is involved in the interaction with the acidic surface side of Drep1 CIDE and Drep3 CIDE.
      Title: General interaction mode of CIDE:CIDE complex revealed by a mutation study of the Drep2 CIDE domain.
    2. Drep2 is a novel nuclease whose activity is inhibited by Drep3 through a tight interaction with the CIDE domain.
      Title: Dual apoptotic DNA fragmentation system in the fly: Drep2 is a novel nuclease of which activity is inhibited by Drep3.
    3. CIDE domains of Drep2 and Drep3 were purified in Escherichia coli, after which they formed a stable complex in vitro and were crystallized by the hanging-drop vapour-diffusion method. X-ray diffraction data were collected to a resolution of 5.8 A.
      Title: Crystallization and preliminary X-ray crystallographic studies of the CIDE-domain complex between Drep2 and Drep3 from Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA fragmentation factor-related protein 3
    Names
    CG8364-PA
    CG8364-PB
    Drep3-PA
    Drep3-PB
    Rep3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12055089..12062866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136879.3 → NP_610723.2  DNA fragmentation factor-related protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610723.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9B7, Q9U786
      Related
      FBpp0087088
      Conserved Domains (1) summary
      cd01615
      Location:119 → 192
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

    2. NM_136878.3 → NP_610722.2  DNA fragmentation factor-related protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610722.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9B7, Q9U786
      Related
      FBpp0087087
      Conserved Domains (1) summary
      cd01615
      Location:119 → 192
      CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E9B7 Q0E9B7
    Q8T4H5 Q8T4H5
    Q9U786 Q9U786

    Gene LinkOut

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