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    Rubicon rubicon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rubiconprovided by FlyBase
    Official Full Name
    rubiconprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030055
    Locus tag
    Dmel_CG12772
    See related
    AllianceGenome:FB:FBgn0030055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12772; Dmel\CG12772; dRubicon; FBgn 30055
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in negative regulation of autophagy. Predicted to be located in early endosome. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to several human genes including RUBCN (rubicon autophagy regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rubicon in Genome Data Viewer
    Location:
    8A1-8A1; 1-24 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8677063..8680912)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8571096..8574945)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Chromatin assembly factor 1, p180 subunit Neighboring gene ocelliless Neighboring gene Carbonic anhydrase 3 Neighboring gene Palmitoyl-protein thioesterase 1 Neighboring gene 8-oxoguanine DNA glycosylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dataset on the effect of Rubicon overexpression on polyglutamine-induced locomotor dysfunction in Drosophila. Oba M, et al. Data Brief, 2021 Aug. PMID 34189208, Free PMC Article
    2. Suppression of autophagic activity by Rubicon is a signature of aging. Nakamura S, et al. Nat Commun, 2019 Feb 19. PMID 30783089, Free PMC Article
    3. Characterization of Drosophila palmitoyl-protein thioesterase 1. Glaser RL, et al. Gene, 2003 Jul 17. PMID 12909364
    4. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
    5. Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization. Ben-Hur S, et al. Nat Commun, 2024 Jul 8. PMID 38977659, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG12772 (Rubicon) negatively regulates autophagy and plays a role in the lifespan.
      Title: Suppression of autophagic activity by Rubicon is a signature of aging.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rubicon
    Names
    CG12772-PA
    CG12772-PB
    Rubicon-PA
    Rubicon-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8677063..8680912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272419.2 → NP_001259348.1  rubicon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYT8, Q9W3C9
      Conserved Domains (1) summary
      pfam13901
      Location:619 → 824
      zf-RING_9; Putative zinc-RING and/or ribbon

    2. NM_132268.2 → NP_572496.1  rubicon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYT8, Q9W3C9
      Related
      FBpp0071166
      Conserved Domains (1) summary
      pfam13901
      Location:619 → 824
      zf-RING_9; Putative zinc-RING and/or ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYT8 Q8MYT8
    Q9W3C9 Q9W3C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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