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    m miniature [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mprovided by FlyBase
    Official Full Name
    miniatureprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002577
    Locus tag
    Dmel_CG9369
    See related
    AllianceGenome:FB:FBgn0002577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9369; Dmel\CG9369; M; min; Min
    Summary
    Predicted to be a structural constituent of chitin-based cuticle. Involved in several processes, including cuticle pattern formation; epithelial cell differentiation; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in trichome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    10E1-10E2; 1-36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11754273..11769508)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11648306..11663541)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene inaF-D Neighboring gene inaF-B Neighboring gene inaF-C Neighboring gene inaF-A Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene dusky Neighboring gene antisense RNA:CR44962 Neighboring gene karl

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The influence of the quantity and quality of chromosomal material on the size of the cells in drosophila melanogaster. Dobzhansky T. Wilhelm Roux Arch Entwickl Mech Org, 1929 Apr. PMID 28353864
    2. In Drosophila hair development, shavenbaby is at the beginning of the end. Robinson R. PLoS Biol, 2006 Sep. PMID 20076640, Free PMC Article
    3. Cytological observations on the interaction between two inversions responsible for position-effect variegation in Drosophila melanogaster. Hartmann-Goldstein IJ, et al. Chromosoma, 1975 Nov 11. PMID 811452
    4. RNA interference from a CAX trinucleotide repeat. Akten B, et al. Genesis, 2002 Sep-Oct. PMID 12324973
    5. Phenotypic observations on modification of position-effect variegation in Drosophila melanogaster. Wargent JM, et al. Heredity (Edinb), 1974 Dec. PMID 4217333

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular matrix protein Miniature is essential for proper progress of apoptosis and, presumably, epithelial-to-mesenchymal transition.
      Title: The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent.
    2. Miniature acts upstream from the heterotrimeric Gs protein transducing the bursicon signal in wing epithelia.
      Title: Role of the gene Miniature in Drosophila wing maturation.
    3. functions as structural component of the Drosophila cuticulin layer
      Title: Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based cuticle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apical constriction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apical constriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of embryonic cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of embryonic cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    miniature
    Names
    CG9369-PA
    m-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11754273..11769508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132519.2 → NP_572747.1  miniature [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYU8
      Related
      FBpp0073400
      Conserved Domains (2) summary
      smart00241
      Location:55 → 286
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:194 → 287
      Zona_pellucida; Zona pellucida-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYU8 Q9VYU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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