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    Lsm12a LSM12 homolog a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsm12aprovided by FlyBase
    Official Full Name
    LSM12 homolog aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030364
    Locus tag
    Dmel_CG15735
    See related
    AllianceGenome:FB:FBgn0030364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD05893; CG15735; Dmel\CG15735; Lsm12
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in nucleus. Is expressed in organism. Orthologous to human LSM12 (LSM12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lsm12a in Genome Data Viewer
    Location:
    11A1-11A1; 1-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12018640..12020719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11912673..11914752)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene regucalcin Neighboring gene Chromatin accessibility complex 16kD protein Neighboring gene Transport and Golgi organization 4 Neighboring gene Ubiquitin-specific protease 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Chung CY, et al. Nat Commun, 2018 Oct 23. PMID 30353006, Free PMC Article
    2. LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons. Lee J, et al. Mol Cell, 2017 Apr 6. PMID 28388438
    3. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    4. Composition of the Survival Motor Neuron (SMN) Complex in Drosophila melanogaster. Matera AG, et al. G3 (Bethesda), 2019 Feb 7. PMID 30563832, Free PMC Article
    5. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Praveen K, et al. Cell Rep, 2012 Jun 28. PMID 22813737, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    LSM12 homolog a
    Names
    CG15735-PA
    LSM12 homolog
    Lsm12a-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12018640..12020719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132549.3 → NP_572777.2  LSM12 homolog a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572777.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0F6, Q9VYR0
      Related
      FBpp0073458
      Conserved Domains (2) summary
      cd01735
      Location:14 → 73
      LSm12_N; Like-Sm protein 12, N-terminal domain
      smart00995
      Location:84 → 175
      AD; Anticodon-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYR0.2 Q9VYR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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