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    Cyp4s3 Cytochrome P450 4s3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4s3provided by FlyBase
    Official Full Name
    Cytochrome P450 4s3provided by FlyBase
    Primary source
    FLYBASE:FBgn0030615
    Locus tag
    Dmel_CG9081
    See related
    AllianceGenome:FB:FBgn0030615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4s3; CG9081; Dmel\CG9081; RE63964
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval fat body. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4s3 in Genome Data Viewer
    Location:
    13A12-13A12; 1-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15113302..15116542, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15007335..15010575, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dihydrolipoamide branched chain transacylase E2 Neighboring gene Rab3 GDP-GTP exchange factor Neighboring gene uncharacterized protein Neighboring gene drop dead Neighboring gene Ribosomal protein L37-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
    2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
    3. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
    4. Differentially expressed profiles in the larval testes of Wolbachia infected and uninfected Drosophila. Zheng Y, et al. BMC Genomics, 2011 Dec 6. PMID 22145623, Free PMC Article
    5. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Bouché V, et al. Autophagy, 2016. PMID 26761346, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4s3
    Names
    CG9081-PA
    Cyp4s3-PA
    cytochrome P450
    NP_573003.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15113302..15116542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132775.3 → NP_573003.2  cytochrome P450 4s3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573003.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VXY0
      UniProtKB/TrEMBL
      I1WYI3, Q8SYF6
      Related
      FBpp0073845
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 469
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYF6 Q8SYF6
    Q9VXY0.1 Q9VXY0

    Gene LinkOut

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