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    Arpc3B Actin-related protein 2/3 complex, subunit 3B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arpc3Bprovided by FlyBase
    Official Full Name
    Actin-related protein 2/3 complex, subunit 3Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0065032
    Locus tag
    Dmel_CG8936
    See related
    AllianceGenome:FB:FBgn0065032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arpc3; Arpc3b; BcDNA:SD24339; CG8936; Dmel\CG8936; P21-ARC
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in imaginal disc fusion, thorax closure. Predicted to be located in cytoskeleton. Predicted to be part of Arp2/3 protein complex. Is expressed in nurse cell ring canal and ovary. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arpc3B in Genome Data Viewer
    Location:
    15E3-15E3; 1-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17104571..17105852, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16998604..16999885, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene meiotic 218 Neighboring gene meiotic 217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex. Hudson AM, et al. J Cell Biol, 2002 Feb 18. PMID 11854308, Free PMC Article
    2. Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster. Salces-Ortiz J, et al. Philos Trans R Soc Lond B Biol Sci, 2020 Mar 30. PMID 32075557, Free PMC Article
    3. Frazzled can act through distinct molecular pathways in epithelial cells to regulate motility, apical constriction, and localisation of E-Cadherin. Golenkina S, et al. PLoS One, 2018. PMID 29518139, Free PMC Article
    4. Identification of functionally important residues of Arp2/3 complex by analysis of homology models from diverse species. Beltzner CC, et al. J Mol Biol, 2004 Feb 13. PMID 14757065
    5. The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis. Lu Q, et al. PLoS One, 2015. PMID 25730111, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Arp2/3 protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Actin-related protein 2/3 complex, subunit 3B
    Names
    Arpc3B-PA
    Arpc3B-PB
    Arpc3B-PC
    CG8936-PA
    CG8936-PB
    CG8936-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17104571..17105852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132965.2 → NP_573193.1  Actin-related protein 2/3 complex, subunit 3B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX82
      Related
      FBpp0074184
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 169
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit

    2. NM_001272711.1 → NP_001259640.1  Actin-related protein 2/3 complex, subunit 3B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV29
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 152
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit

    3. NM_001103539.2 → NP_001097009.1  Actin-related protein 2/3 complex, subunit 3B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097009.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV29
      Conserved Domains (1) summary
      pfam04062
      Location:1 → 152
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JV29 A8JV29
    Q9VX82 Q9VX82

    Gene LinkOut

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