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    CG18304 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18304provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031869
    Locus tag
    Dmel_CG18304
    See related
    AllianceGenome:FB:FBgn0031869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13774; Dmel\CG18304
    Summary
    Is expressed in adult head and spermatozoon. Orthologous to human MTCL3 (MTCL family member 3); MTCL1 (microtubule crosslinking factor 1); and MTCL2 (microtubule crosslinking factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18304 in Genome Data Viewer
    Location:
    27C4-27C6; 2-23 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6932545..6942814, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6932545..6942814, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene x16 splicing factor Neighboring gene nop5 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 27C Neighboring gene uncharacterized protein Neighboring gene Fibroblast growth factor receptor 1 oncogene partner 2 Neighboring gene interference hedgehog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis P, et al. BMC Dev Biol, 2010 Oct 19. PMID 20959007, Free PMC Article
    2. Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases. Marcogliese PC, et al. Cell Rep, 2022 Mar 15. PMID 35294868, Free PMC Article
    3. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article
    4. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article
    5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18304-PA
    CG18304-PB
    CG18304-PC
    CG18304-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6932545..6942814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273240.1 → NP_001260169.1  uncharacterized protein Dmel_CG18304, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCS5
      Conserved Domains (4) summary
      COG1196
      Location:399 → 1276
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09798
      Location:1397 → 1506
      LCD1; DNA damage checkpoint protein
      pfam11365
      Location:604 → 707
      DUF3166; Protein of unknown function (DUF3166)
      cl21478
      Location:1092 → 1143
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_135239.4 → NP_609083.2  uncharacterized protein Dmel_CG18304, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609083.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM66, Q9VM67
      Conserved Domains (4) summary
      COG1196
      Location:398 → 1196
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09798
      Location:1479 → 1588
      LCD1; DNA damage checkpoint protein
      pfam10481
      Location:1006 → 1280
      CENP-F_N; Cenp-F N-terminal domain
      cl21478
      Location:1174 → 1225
      ATP-synt_B; ATP synthase B/B' CF(0)

    3. NM_001258992.2 → NP_001245921.1  uncharacterized protein Dmel_CG18304, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NCS3
      Conserved Domains (4) summary
      COG1196
      Location:405 → 1282
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09798
      Location:1403 → 1512
      LCD1; DNA damage checkpoint protein
      pfam11365
      Location:610 → 713
      DUF3166; Protein of unknown function (DUF3166)
      cl21478
      Location:1098 → 1149
      ATP-synt_B; ATP synthase B/B' CF(0)

    4. NM_001273241.1 → NP_001260170.1  uncharacterized protein Dmel_CG18304, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCE3
      Conserved Domains (4) summary
      COG1196
      Location:404 → 1202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09798
      Location:1485 → 1594
      LCD1; DNA damage checkpoint protein
      pfam10481
      Location:1012 → 1286
      CENP-F_N; Cenp-F N-terminal domain
      cl21478
      Location:1180 → 1231
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCS3 M9NCS3
    M9PCE3 M9PCE3
    M9PCS5 M9PCS5
    Q9VM67 Q9VM67

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