Nthl1 Nth-like DNA glycosylase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nthl1provided by FlyBase
Official Full Name: Nth-like DNA glycosylase 1provided by FlyBase
Primary source: FLYBASE:FBgn0032907
Locus tag: Dmel_CG9272
See related: AllianceGenome:FB:FBgn0032907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 9272; CG9272; Dmel\CG9272; Nth1; NTHL1
Summary: Predicted to enable class I DNA-(apurinic or apyrimidinic site) endonuclease activity and oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation and nucleotide-excision repair. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20926319..20927860, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20926319..20927860, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair, AP site formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair, AP site formation	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair, AP site formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleotide-excision repair	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

NP_610078.2

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The following sections contain reference sequences that belong to a specific genome build. Explain