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    Mpp6 M-phase phosphoprotein 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpp6provided by FlyBase
    Official Full Name
    M-phase phosphoprotein 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0032921
    Locus tag
    Dmel_CG9250
    See related
    AllianceGenome:FB:FBgn0032921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE45276; CG9250; Dmel\CG9250; dMPP6; l(2)k16403; mpp6; MPP6; Mpps
    Summary
    Predicted to be involved in maturation of 5.8S rRNA. Is expressed in organism. Orthologous to human MPHOSPH6 (M-phase phosphoprotein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mpp6 in Genome Data Viewer
    Location:
    39A6-39A6; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21156288..21157685)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21156288..21157685)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene porthos Neighboring gene deadlock Neighboring gene E2F transcription factor 2 Neighboring gene Coenzyme Q3 Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional antagonism between E2F family members. Frolov MV, et al. Genes Dev, 2001 Aug 15. PMID 11511545, Free PMC Article
    2. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Moon NS, et al. Dev Cell, 2005 Oct. PMID 16198289
    3. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu P, et al. Development, 2001 Dec. PMID 11748144
    4. The Integrator complex cleaves nascent mRNAs to attenuate transcription. Tatomer DC, et al. Genes Dev, 2019 Nov 1. PMID 31530651, Free PMC Article
    5. A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor. Raicu AM, et al. J Biol Chem, 2024 Jan. PMID 38000659, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    M-phase phosphoprotein 6
    Names
    CG9250-PA
    CG9250-PB
    Mpp6-PA
    Mpp6-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21156288..21157685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078885.3 → NP_523609.3  M-phase phosphoprotein 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523609.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PE4, Q9VIF4
      Related
      FBpp0080998
      Conserved Domains (1) summary
      pfam10175
      Location:8 → 133
      MPP6; M-phase phosphoprotein 6

    2. NM_001299187.1 → NP_001286116.1  M-phase phosphoprotein 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PE4, Q9VIF4
      Conserved Domains (1) summary
      pfam10175
      Location:8 → 133
      MPP6; M-phase phosphoprotein 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95PE4 Q95PE4

    Gene LinkOut

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