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    Corin corin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Corinprovided by FlyBase
    Official Full Name
    corinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033192
    Locus tag
    Dmel_CG2105
    See related
    AllianceGenome:FB:FBgn0033192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2105; corin; Dmel\CG2105; SP75
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Corin in Genome Data Viewer
    Location:
    43D3-43D7; 2-56 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7540111..7564435)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3427616..3451940)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome b5 Neighboring gene Glycerophosphate oxidase 2 Neighboring gene uncharacterized protein Neighboring gene Ribulose-5-phosphate-3-epimerase Neighboring gene boca Neighboring gene Vacuolar protein sorting 13 Neighboring gene antisense RNA:CR45130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Crystal Structure of the NHL Domain in Complex with RNA Reveals the Molecular Basis of Drosophila Brain-Tumor-Mediated Gene Regulation. Loedige I, et al. Cell Rep, 2015 Nov 10. PMID 26527002
    2. Paternal diet affects differential gene expression, but not sperm competition, in sons. Zajitschek F, et al. Biol Lett, 2017 Feb. PMID 28202685, Free PMC Article
    3. A genome-wide analysis of immune responses in Drosophila. Irving P, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742098, Free PMC Article
    4. Evolution of a cellular immune response in Drosophila: a phenotypic and genomic comparative analysis. Salazar-Jaramillo L, et al. Genome Biol Evol, 2014 Feb. PMID 24443439, Free PMC Article
    5. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    corin
    Names
    CG2105-PB
    CG2105-PC
    Corin-PB
    Corin-PC
    DCorin
    NP_610297.2
    NP_995773.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7540111..7564435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136453.3 → NP_610297.2  corin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610297.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z709
      Conserved Domains (6) summary
      cd07066
      Location:778 → 894
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      smart00020
      Location:1103 → 1343
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:980 → 1034
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:945 → 979
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:1104 → 1346
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:992 → 1086
      SRCR; Scavenger receptor cysteine-rich domain

    2. NM_206051.4 → NP_995773.1  corin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z709
      Conserved Domains (6) summary
      cd07066
      Location:778 → 894
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      smart00020
      Location:1103 → 1343
      Tryp_SPc; Trypsin-like serine protease
      smart00202
      Location:980 → 1034
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:945 → 979
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:1104 → 1346
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:992 → 1086
      SRCR; Scavenger receptor cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z709 A1Z709

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