Tmem63 Transmembrane protein 63 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tmem63provided by FlyBase
Official Full Name: Transmembrane protein 63provided by FlyBase
Primary source: FLYBASE:FBgn0033259
Locus tag: Dmel_CG11210
See related: AllianceGenome:FB:FBgn0033259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11210; CT31310; Dmel\CG11210; OSCA/TMEM63; tmem63; TMEM63
Summary: Enables mechanosensitive monoatomic cation channel activity. Involved in detection of humidity stimulus involved in sensory perception; monoatomic cation transmembrane transport; and regulation of response to food. Located in apical part of cell and cytoplasm. Is expressed in several structures, including adult Malpighian tubule; adult brain; adult fat body; gastric caecum; and organism subdivision. Used to study central nervous system disease. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87 and hypomyelinating leukodystrophy 19. Orthologous to human TMEM63A (transmembrane protein 63A); TMEM63B (transmembrane protein 63B); and TMEM63C (transmembrane protein 63C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8098684..8102306)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3986189..3989811)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.
Title: Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.
Mechanism for food texture preference based on grittiness.
Title: Mechanism for food texture preference based on grittiness.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables calcium-activated cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables mechanosensitive monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in detection of humidity stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of response to food	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain