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    L Lobe [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lprovided by FlyBase
    Official Full Name
    Lobeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0288433
    Locus tag
    Dmel_CG42702
    See related
    AllianceGenome:FB:FBgn0288433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17388; CG17389; CG17390; CG42702; Dmel\CG42702; dmOAZ; Dm_2R:42259; fee; l(2)03563; oaz; Oaz
    Old locus tag
    Dmel_CG17388; Dmel_CG17389; Dmel_CG17390
    Summary
    Involved in spiracle morphogenesis, open tracheal system. Predicted to be located in nucleus. Is expressed in several structures, including Bolwig organ primordium; anlage in statu nascendi; brain; cuboidal/columnar epithelium; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    51A2-51A4; 2-71 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14435899..14465881)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10323404..10353386)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45277 Neighboring gene phyllopod Neighboring gene long non-coding RNA:CR44462 Neighboring gene Proline-rich Akt substrate 40 kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Classic Lobe Eye Phenotype of Drosophila Is Caused by Transposon Insertion-Induced Misexpression of a Zinc-Finger Transcription Factor.
      Title: The Classic Lobe Eye Phenotype of Drosophila Is Caused by Transposon Insertion-Induced Misexpression of a Zinc-Finger Transcription Factor.
    2. DmOAZ, the unique Drosophila melanogaster homologue of the OAZ zinc finger protein family, was studied.
      Title: DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in posterior spiracle development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lobe
    Names
    CG42702-PB
    CG42702-PC
    L-PB
    L-PC
    O/E-associated zinc finger protein
    freaky eye
    lethal (2) 03563

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14435899..14465881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202000.2 → NP_001188929.1  lobe, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD76
      Conserved Domains (4) summary
      COG5048
      Location:336 → 769
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:294 → 314
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:348 → 370
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:334 → 359
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001103845.3 → NP_001097315.1  lobe, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9R4, Q8T496
      Conserved Domains (4) summary
      COG5048
      Location:198 → 631
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:156 → 176
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:210 → 232
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:196 → 221
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD76 A0A0B4JD76
    A1Z9R4.2 A1Z9R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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