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    EndoB Endophilin B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EndoBprovided by FlyBase
    Official Full Name
    Endophilin Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034433
    Locus tag
    Dmel_CG9834
    See related
    AllianceGenome:FB:FBgn0034433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9834; D-endoB; D-EndoB; Dmel\CG9834; endoB
    Summary
    Involved in clathrin-dependent endocytosis involved in vitellogenesis and membrane organization. Located in membrane. Is expressed in several structures, including adult head; embryonic antennal sense organ; female germline cell; and ganglia. Orthologous to several human genes including SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EndoB in Genome Data Viewer
    Location:
    56C10-56C10; 2-88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19307447..19310665, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15194952..15198170, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TAK1-associated binding protein 2 Neighboring gene Acyl-CoA dehydrogenase very long chain Neighboring gene Rad, Gem/Kir family member 1 Neighboring gene uncharacterized protein Neighboring gene wurstfest

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An encore for kiss and run? Marte B. Nat Cell Biol, 2002 May. PMID 11988753
    2. Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. Guichet A, et al. EMBO J, 2002 Apr 2. PMID 11927550, Free PMC Article
    3. Endophilin-B regulates autophagy during synapse development and neurodegeneration. Hernandez-Diaz S, et al. Neurobiol Dis, 2022 Feb. PMID 34933093
    4. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Chang KT, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805187, Free PMC Article
    5. The CHD Protein Kismet Restricts the Synaptic Localization of Cell Adhesion Molecules at the Drosophila Neuromuscular Junction. Smith IR, et al. Int J Mol Sci, 2024 Mar 6. PMID 38474321, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endophilin-B regulates autophagy during synapse development and neurodegeneration.
      Title: Endophilin-B regulates autophagy during synapse development and neurodegeneration.
    2. These results allow us to conclude that D-EndoB contributes to the endocytic activity downstream of Oskar by facilitating membrane dynamics through its N-BAR domain.
      Title: Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis involved in vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane tubulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    endophilin B
    Names
    CG9834-PA
    CG9834-PB
    CG9834-PC
    CG9834-PD
    EndoB-PA
    EndoB-PB
    EndoB-PC
    EndoB-PD
    Endophilin-B
    endophilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19307447..19310665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166340.3 → NP_725873.1  endophilin B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGU0, Q8T389, Q9V8T2
      Related
      FBpp0085743
      Conserved Domains (2) summary
      cd07594
      Location:26 → 254
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
      cd11802
      Location:315 → 366
      SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

    2. NM_001103906.3 → NP_001097376.1  endophilin B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYJ0
      Conserved Domains (2) summary
      cd07594
      Location:26 → 254
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
      cl17036
      Location:325 → 354
      SH3; Src Homology 3 domain superfamily

    3. NM_137566.4 → NP_611410.1  endophilin B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611410.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGU0, Q8SYD9
      Related
      FBpp0085742
      Conserved Domains (2) summary
      cd07594
      Location:26 → 266
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
      cd11802
      Location:327 → 378
      SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

    4. NM_001103905.3 → NP_001097375.1  endophilin B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYJ1
      Conserved Domains (2) summary
      cd07594
      Location:26 → 266
      BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
      cl17036
      Location:337 → 366
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYJ0 A8DYJ0
    A8DYJ1 A8DYJ1
    Q8IGU0 Q8IGU0
    Q8SYD9 Q8SYD9
    Q8T389 Q8T389

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