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    RpL12 Ribosomal protein L12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpL12provided by FlyBase
    Official Full Name
    Ribosomal protein L12provided by FlyBase
    Primary source
    FLYBASE:FBgn0034968
    Locus tag
    Dmel_CG3195
    See related
    AllianceGenome:FB:FBgn0034968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey236; CG3195; Dmel\CG3195; L11; L12; Q9W1B9_DROME; Rp L12; Rpl12; RPL12; uL11
    Summary
    A structural constituent of ribosome. Predicted to be involved in translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; germline cell; and organism. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL12 (ribosomal protein L12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpL12 in Genome Data Viewer
    Location:
    60B7-60B7; 2-106 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24060378..24061860)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19947901..19949383)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44814 Neighboring gene eukaryotic translation elongation factor 5 Neighboring gene Ribosomal protein L39 Neighboring gene Ras-associated protein 2-like Neighboring gene yorkie

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single amino-acid mutation in a Drosoph ila melanogaster ribosomal protein: An insight in uL11 transcriptional activity. Grunchec H, et al. PLoS One, 2022. PMID 35981051, Free PMC Article
    2. Drosophila vigilin, DDP1, localises to the cytoplasm and associates to the rough endoplasmic reticulum. Batlle M, et al. Biochim Biophys Acta, 2011 Jan. PMID 21035573
    3. New partners in regulation of gene expression: the enhancer of Trithorax and Polycomb Corto interacts with methylated ribosomal protein l12 via its chromodomain. Coléno-Costes A, et al. PLoS Genet, 2012. PMID 23071455, Free PMC Article
    4. Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast. Junell A, et al. Insect Biochem Mol Biol, 2007 Mar. PMID 17296495
    5. A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies. Laslo M, et al. Age (Dordr), 2013 Aug. PMID 22639178, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein L12
    Names
    CG3195-PA
    CG3195-PB
    CG3195-PC
    RpL12-PA
    RpL12-PB
    RpL12-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24060378..24061860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166656.2 → NP_726413.1  ribosomal protein L12, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1B9
      Related
      FBpp0072083
      Conserved Domains (1) summary
      PLN03072
      Location:1 → 165
      PLN03072; 60S ribosomal protein L12; Provisional

    2. NM_080080.3 → NP_524819.1  ribosomal protein L12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1B9
      Related
      FBpp0072084
      Conserved Domains (1) summary
      PLN03072
      Location:1 → 165
      PLN03072; 60S ribosomal protein L12; Provisional

    3. NM_166655.2 → NP_726412.1  ribosomal protein L12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726412.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1B9
      Related
      FBpp0072085
      Conserved Domains (1) summary
      PLN03072
      Location:1 → 165
      PLN03072; 60S ribosomal protein L12; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1B9 Q9W1B9

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