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    galene galene [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    galeneprovided by FlyBase
    Official Full Name
    galeneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035192
    Locus tag
    Dmel_CG9194
    See related
    AllianceGenome:FB:FBgn0035192
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0109301.19; anon-WO0109301.20; anon-WO0109301.21; anon-WO0109301.22; anon-WO0109301.23; anon-WO0109301.24; anon-WO0109301.25; anon-WO0109301.26; anon-WO0109301.27; anon-WO0109301.28; anon-WO0109301.29; anon-WO0109301.3; anon-WO0109301.31; anon-WO0109301.32; anon-WO0109301.33; anon-WO0109301.34; anon-WO0109301.36; anon-WO0109301.37; anon-WO0109301.38; C9194; CG9194; Dmel\CG9194
    Summary
    Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in dorsal pharyngeal muscle cell; larval muscle system; and larval somatic muscle cell. Used to study heart conduction disease. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See galene in Genome Data Viewer
    Location:
    61F4-61F4; 3-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1235726..1242025)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1235726..1242025)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45747 Neighboring gene uncharacterized protein Neighboring gene Kinesin-like protein at 61F Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Age-dependent diastolic heart failure in an in vivo Drosophila model. Klassen MP, et al. Elife, 2017 Mar 22. PMID 28328397, Free PMC Article
    2. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
    3. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Wei HC, et al. Genome, 2003 Dec. PMID 14663523
    4. Operation of a homeostatic sleep switch. Pimentel D, et al. Nature, 2016 Aug 18. PMID 27487216, Free PMC Article
    5. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. Wilczynski B, et al. PLoS Comput Biol, 2012. PMID 23236268, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    galene
    Names
    CG9194-PA
    galene-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1235726..1242025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138240.2 → NP_612084.1  galene [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR05, Q9W0J0
      Related
      FBpp0072545
      Conserved Domains (3) summary
      pfam06390
      Location:341 → 586
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      pfam00520
      Location:621 → 709
      Ion_trans; Ion transport protein
      pfam07885
      Location:134 → 189
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NR05 Q6NR05
    Q9W0J0 Q9W0J0

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