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    CG8492 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8492provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035813
    Locus tag
    Dmel_CG8492
    See related
    AllianceGenome:FB:FBgn0035813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8492
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Used to study viral infectious disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8492 in Genome Data Viewer
    Location:
    66A11-66A11; 3-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7727804..7732191, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7720904..7725291, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ankyrin 2 Neighboring gene uncharacterized protein Neighboring gene Medium-chain acyl-CoA dehydrogenase Neighboring gene Sensory neuron membrane protein 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host adaptation to viruses relies on few genes with different cross-resistance properties. Martins NE, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24711428, Free PMC Article
    2. Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands. Moulos P, et al. BMC Genomics, 2018 Jul 13. PMID 30005604, Free PMC Article
    3. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Joos JP, et al. Sci Rep, 2018 Feb 13. PMID 29440697, Free PMC Article
    4. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article
    5. The loss of histone H3 lysine 9 acetylation due to dSAGA-specific dAda2b mutation influences the expression of only a small subset of genes. Zsindely N, et al. Nucleic Acids Res, 2009 Nov. PMID 19740772, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8492-PD
    NP_648151.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7727804..7732191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139894.3 → NP_648151.2  uncharacterized protein Dmel_CG8492 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648151.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSA5
      Conserved Domains (2) summary
      cd00119
      Location:596 → 723
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
      pfam17061
      Location:937 → 1068
      PARM; PARM
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSA5 Q9VSA5

    Gene LinkOut

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