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    CG10903 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40952, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10903provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037543
    Locus tag
    Dmel_CG10903
    See related
    AllianceGenome:FB:FBgn0037543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10903
    Summary
    Predicted to enable rRNA (guanine) methyltransferase activity. Predicted to be involved in rRNA (guanine-N7)-methylation. Predicted to be active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human BUD23 (BUD23 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10903 in Genome Data Viewer
    Location:
    84E9-84E9; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8030411..8032145)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3856133..3857867)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene PSEA-binding protein 95kD Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncoordinated 45 Neighboring gene long non-coding RNA:CR44936

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. Liu M, et al. G3 (Bethesda), 2015 Nov 6. PMID 26546310, Free PMC Article
    2. E2 ligase dRad6 regulates DMP53 turnover in Drosophila. Chen S, et al. J Biol Chem, 2011 Mar 18. PMID 21205821, Free PMC Article
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
    5. Identification of genetic suppressors of the Sin3A knockdown wing phenotype. Swaminathan A, et al. PLoS One, 2012. PMID 23166712, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables rRNA (guanine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (guanine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA (guanine-N7)-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10903-PA
    CG10903-PB
    NP_001262365.1
    NP_649762.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8030411..8032145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275436.1 → NP_001262365.1  uncharacterized protein Dmel_CG10903, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHW6
      Conserved Domains (2) summary
      pfam08241
      Location:56 → 142
      Methyltransf_11; Methyltransferase domain
      pfam12589
      Location:202 → 272
      WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome

    2. NM_141505.4 → NP_649762.1  uncharacterized protein Dmel_CG10903, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHW6
      Related
      FBpp0081283
      Conserved Domains (2) summary
      pfam08241
      Location:56 → 142
      Methyltransf_11; Methyltransferase domain
      pfam12589
      Location:202 → 272
      WBS_methylT; Methyltransferase involved in Williams-Beuren syndrome
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHW6 Q9VHW6

    Gene LinkOut

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