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    Task7 TWIK-related acid-sensitive K[+] channel 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Task7provided by FlyBase
    Official Full Name
    TWIK-related acid-sensitive K[+] channel 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0037690
    Locus tag
    Dmel_CG9361
    See related
    AllianceGenome:FB:FBgn0037690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9361; Dmel\CG9361; dmTASK7; dTASK-7; K2P-TASK7; TASK-7
    Summary
    Enables potassium channel activity and protein heterodimerization activity. Involved in potassium ion transmembrane transport. Located in membrane. Is expressed in several structures, including adult brain cell body rind; anterior-posterior subdivision of organism; and cell body rind of adult antennal lobe. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Orthologous to several human genes including KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Task7 in Genome Data Viewer
    Location:
    85D15-85D15; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9410329..9412293, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5236051..5238015, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene BBSome interacting protein 1 Neighboring gene beta-Tubulin at 85D Neighboring gene uncharacterized protein Neighboring gene alpha-Mannosidase class II a Neighboring gene pasilla

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hormonal control of motivational circuitry orchestrates the transition to sexuality in Drosophila. Zhang SX, et al. Sci Adv, 2021 Jun. PMID 34134981, Free PMC Article
    2. Small conductance Ca(2+)-activated K(+) channels induce the firing pause periods during the activation of Drosophila nociceptive neurons. Onodera K, et al. Elife, 2017 Oct 16. PMID 29035200, Free PMC Article
    3. The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes. Luna-Peláez N, et al. Cell Death Dis, 2019 Jul 18. PMID 31320616, Free PMC Article
    4. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
    5. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TWIK-related acid-sensitive K[+] channel 7
    Names
    CG9361-PA
    Task7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9410329..9412293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141634.2 → NP_649891.1  TWIK-related acid-sensitive K[+] channel 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3ZZY0, Q9VHE0
      Related
      FBpp0081523
      Conserved Domains (1) summary
      pfam07885
      Location:166 → 248
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZZY0 Q3ZZY0
    Q9VHE0 Q9VHE0

    Gene LinkOut

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