Sirt6 Sirtuin 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sirt6provided by FlyBase
Official Full Name: Sirtuin 6provided by FlyBase
Primary source: FLYBASE:FBgn0037802
Locus tag: Dmel_CG6284
See related: AllianceGenome:FB:FBgn0037802
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6284; D.mel4; Dmel\CG6284; dmSRT408; dSIRT6; sirt6
Summary: Enables NAD-dependent histone H3K9 deacetylase activity. Involved in determination of adult lifespan; negative regulation of DNA methylation-dependent heterochromatin formation; and negative regulation of transcription by RNA polymerase II. Located in chromatin. Is active in nucleus. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 86A2-86A3; 3-49 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10255349..10261849, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6081071..6087571, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7.
Title: Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7.
Sirt6 regulates lifespan in Drosophila melanogaster.
Title: Sirt6 regulates lifespan in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c10257395-10255433 mobile_element_type = transposon:I{}Sirt6-iso-1a

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K9 deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone deacetylase activity, NAD-dependent	NAS Non-traceable Author Statement more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sirtuin 6

Names: CG6284-PB; Sirt6-PB

NP_649990.2

EC 3.5.1.98

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

10255349..10261849 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141733.3 → NP_649990.2 sirtuin 6 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649990.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F3YD73, Q9VH08

Conserved Domains (1) summary

cd01410
Location:45 → 258

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...