Hmx H6-like-homeobox [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hmxprovided by FlyBase
Official Full Name: H6-like-homeoboxprovided by FlyBase
Primary source: FLYBASE:FBgn0264005
Locus tag: Dmel_CG43748
See related: AllianceGenome:FB:FBgn0264005
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18139; CG34419; CG43748; CG5829; CG5832; DHmx; Dmel\CG43748; hmx
Old locus tag: CG5829; CG5832; Dmel_CG18139; Dmel_CG34419; Dmel_CG5829; Dmel_CG5832
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; central brain anlage; central brain anlage in statu nascendi; and ganglia. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Orthologous to human HMX1 (H6 family homeobox 1); HMX2 (H6 family homeobox 2); and HMX3 (H6 family homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 90B4-90B5; 3-61 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17558930..17569097)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13384652..13394819)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info