U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rassf Ras association family member [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42734, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rassfprovided by FlyBase
    Official Full Name
    Ras association family memberprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039055
    Locus tag
    Dmel_CG4656
    See related
    AllianceGenome:FB:FBgn0039055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4656; Dmel\CG4656; dmRASSF; dRassf; dRassF; dRASSF; dRASSF1; rassf; RASSF
    Summary
    Involved in defense response to virus; regulation of growth; and regulation of signal transduction. Orthologous to several human genes including RASSF2 (Ras association domain family member 2) and RASSF4 (Ras association domain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rassf in Genome Data Viewer
    Location:
    94D13-94E1; 3-78 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23114014..23117931, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18939736..18943653, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carrier of Wingless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Centaurin beta 1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Biophysical characterization of SARAH domain-mediated multimerization of Hippo pathway complexes in Drosophila. Cairns L, et al. J Biol Chem, 2020 May 1. PMID 32213597, Free PMC Article
    2. Quantitative proteomics reveals rapid divergence in the postmating response of female reproductive tracts among sibling species. McCullough EL, et al. Proc Biol Sci, 2020 Jun 24. PMID 32576111, Free PMC Article
    3. Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Hergovich A, et al. Semin Cell Dev Biol, 2012 Sep. PMID 22525225, Free PMC Article
    4. One Hippo and many masters: differential regulation of the Hippo pathway in cancer. Romano D, et al. Biochem Soc Trans, 2014 Aug. PMID 25109963
    5. The Drosophila RASSF homolog antagonizes the hippo pathway. Polesello C, et al. Curr Biol, 2006 Dec 19. PMID 17174922, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ras association family member
    Names
    CG4656-PA
    Ras-associated domain family protein
    Rassf-PA
    dRASSF
    drosophila Ras association family

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23114014..23117931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142869.5 → NP_651126.3  Ras association family member [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651126.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960Q0, Q9VCQ7
      Conserved Domains (3) summary
      cd09401
      Location:4 → 57
      LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
      pfam16517
      Location:762 → 799
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cl00155
      Location:660 → 744
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCQ7 Q9VCQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools