dysf dysfusion [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dysfprovided by FlyBase
Official Full Name: dysfusionprovided by FlyBase
Primary source: FLYBASE:FBgn0039411
Locus tag: Dmel_CG32474
See related: AllianceGenome:FB:FBgn0039411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12561; CG14552; CG14553; CG14554; CG32474; Dmel\CG32474; dNXFL; dys; Dys; Dysf; DYSF; NXFL
Summary: Enables protein heterodimerization activity. Contributes to DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in imaginal disc-derived leg joint morphogenesis; open tracheal system development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including anal pad primordium; cardiogenic mesoderm; embryonic/larval tracheal section; gut section; and tracheal branch primordium. Orthologous to human NPAS4 (neuronal PAS domain protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96F12-96F14; 3-89 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (26076592..26098711, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21902314..21924433, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that Dysf-regulated Rho1 activity controls the cell shape changes that sculpt leg joints.
Title: The transcription factor Dysfusion promotes fold and joint morphogenesis through regulation of Rho1.
Dysfusion dimerizes with the Tango bHLH-PAS protein, and together they act as a DNA binding transcriptional activator
Title: Transcriptional specificity of Drosophila dysfusion and the control of tracheal fusion cell gene expression.
competitive interactions between basic helix-loop-helix-PAS proteins (Dysfusion, Trachealess, and possibly Similar) may be important for the proper development of the trachea
Title: The Drosophila dysfusion basic helix-loop-helix (bHLH)-PAS gene controls tracheal fusion and levels of the trachealess bHLH-PAS protein.
dysfusion mutants were isolated, and genetic analysis of live embryos revealed that mutant tracheal branches migrate to close proximity but fail to recognize and adhere to each other.
Title: Dysfusion transcriptional control of Drosophila tracheal migration, adhesion, and fusion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in branch fusion, open tracheal system	IEP Inferred from Expression Pattern more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg joint morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: dysfusion

Names: CG32474-PB; CG32474-PC; CG32474-PD; NXF-like-factor; cranky; dysf-PB; dysf-PC; dysf-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

26076592..26098711 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170258.4 → NP_733137.3 dysfusion, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733137.3

Status: REVIEWED

UniProtKB/TrEMBL

A7VJJ6, Q9VBH3

Conserved Domains (3) summary

smart00091
Location:235 → 292

PAS; PAS domain

cd00130
Location:407 → 506

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:408 → 517

PAS_11; PAS domain
NM_001104466.2 → NP_001097936.1 dysfusion, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097936.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JRD5, Q2WGN8

Conserved Domains (3) summary

smart00091
Location:235 → 292

PAS; PAS domain

cd00130
Location:407 → 506

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:408 → 517

PAS_11; PAS domain
NM_001104465.2 → NP_001097935.1 dysfusion, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097935.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JRD4, Q6RZA5

Conserved Domains (3) summary

smart00091
Location:199 → 256

PAS; PAS domain

cd00130
Location:371 → 470

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:372 → 481

PAS_11; PAS domain