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    osy oskyddad [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    osyprovided by FlyBase
    Official Full Name
    oskyddadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053970
    Locus tag
    Dmel_CG33970
    See related
    AllianceGenome:FB:FBgn0053970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14559; CG31085; CG33970; CG6162; CG6166; DmCG33970; Dmel\CG33970; Osy
    Summary
    Predicted to enable ABC-type transporter activity; ATP binding activity; and ATP hydrolysis activity. Located in apical plasma membrane. Is expressed in several structures, including adult fat body; adult head; embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. Used to study autosomal recessive congenital ichthyosis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See osy in Genome Data Viewer
    Location:
    97A8-97A10; 3-90 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26318355..26362588)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22144077..22188310)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44321 Neighboring gene Aldolase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42765 Neighboring gene Nilkantha Neighboring gene pickpocket 15 Neighboring gene Aldolase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of Oskyddad causes Harlequin-type ichthyosis-like defects in Drosophila melanogaster. Wang Y, et al. PLoS Genet, 2020 Jan. PMID 31929524, Free PMC Article
    2. Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing. Macdonald SJ, et al. Genetics, 2022 Mar 3. PMID 35100395, Free PMC Article
    3. Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier in Drosophila suzukii and Drosophila melanogaster. Wang Y, et al. Front Genet, 2020. PMID 32849846, Free PMC Article
    4. Toxicological Study and Genetic Basis of BTEX Susceptibility in Drosophila melanogaster. Adebambo TH, et al. Front Genet, 2020. PMID 33193742, Free PMC Article
    5. Toxicity of Dithiothreitol (DTT) to Drosophila melanogaster. Wang Y, et al. Toxicol Rep, 2021. PMID 33425686, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oskyddad
    Names
    CG33970-PA
    CG33970-PB
    CG33970-PC
    osy-PA
    osy-PB
    osy-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26318355..26362588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300613.1 → NP_001287542.1  oskyddad, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287542.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P18
      Conserved Domains (4) summary
      COG1131
      Location:54 → 321
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam01061
      Location:581 → 738
      ABC2_membrane; ABC-2 type transporter
      pfam12698
      Location:394 → 770
      ABC2_membrane_3; ABC-2 family transporter protein
      cl21455
      Location:48 → 270
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001038982.2 → NP_001034071.1  oskyddad, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P18
      Conserved Domains (4) summary
      COG1131
      Location:54 → 321
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam01061
      Location:581 → 738
      ABC2_membrane; ABC-2 type transporter
      pfam12698
      Location:394 → 770
      ABC2_membrane_3; ABC-2 family transporter protein
      cl21455
      Location:48 → 270
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001038981.2 → NP_001034070.1  oskyddad, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034070.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBF7
      Conserved Domains (2) summary
      pfam01061
      Location:322 → 479
      ABC2_membrane; ABC-2 type transporter
      pfam12698
      Location:135 → 511
      ABC2_membrane_3; ABC-2 family transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P18 Q86P18
    Q95U16 Q95U16
    Q9VBF7 Q9VBF7

    Gene LinkOut

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