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    Pgam5 Phosphoglycerate mutase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgam5provided by FlyBase
    Official Full Name
    Phosphoglycerate mutase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0023517
    Locus tag
    Dmel_CG14816
    See related
    AllianceGenome:FB:FBgn0023517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14816; Dmel\CG14816; dPGAM5; DPGAM5; EG:63B12.4; pgam5; PGAM5
    Summary
    Enables kinase binding activity; protein serine/threonine kinase activator activity; and protein serine/threonine phosphatase activity. Involved in several processes, including protein dephosphorylation; regulation of mitochondrion organization; and response to anesthetic. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgam5 in Genome Data Viewer
    Location:
    2B13-2B13; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1872400..1873565, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1766433..1767598, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Germ cell nuclear acidic peptidase Neighboring gene Mediator complex subunit 18 Neighboring gene Peroxin 5 Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics. Nag S, et al. Cell Rep, 2023 Aug 29. PMID 37498743
    2. Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. Ishida Y, et al. PLoS One, 2012. PMID 22347370, Free PMC Article
    3. PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila. Borch Jensen M, et al. Elife, 2017 Sep 11. PMID 28891792, Free PMC Article
    4. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Takeda K, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19590015, Free PMC Article
    5. Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. Campbell JL, et al. J Neurogenet, 2009. PMID 19863272, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors show that developmental mitochondrial unfolded protein response is necessary and sufficient to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. Developmental mitochondrial stress leads to activation of FoxO, via Apoptosis Signal-regulating Kinase 1 (ASK1) and Jun-N-terminal Kinase (JNK).
      Title: PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila.
    2. the mushroom body may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for heat shock resistance.
      Title: Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
    3. PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria.
      Title: The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables phosphoglycerate mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoglycerate mutase 5
    Names
    CG14816-PA
    CG14816-PB
    Pgam5-PA
    Pgam5-PB
    NP_001284795.1
    NP_569951.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1872400..1873565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297866.1 → NP_001284795.1  phosphoglycerate mutase 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JC94
      Conserved Domains (1) summary
      cd07067
      Location:88 → 264
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. NM_130595.3 → NP_569951.1  phosphoglycerate mutase 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46084, Q7K2X2
      Related
      FBpp0070350
      Conserved Domains (1) summary
      cd07067
      Location:88 → 265
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46084.1 O46084
    X2JC94 X2JC94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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