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    Alp6 Alkaline phosphatase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alp6provided by FlyBase
    Official Full Name
    Alkaline phosphatase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0033423
    Locus tag
    Dmel_CG1809
    See related
    AllianceGenome:FB:FBgn0033423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1809; Dmel\CG1809
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in adult head; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alp6 in Genome Data Viewer
    Location:
    45F1-45F1; 2-61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9561638..9563871)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5449143..5451376)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43651 Neighboring gene mir-14 stem loop Neighboring gene antisense RNA:CR45281 Neighboring gene Odorant receptor 45b Neighboring gene Not1 Neighboring gene long non-coding RNA:CR46257 Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Jin W, et al. Nat Genet, 2001 Dec. PMID 11726925
    2. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
    3. Seizure suppression by gain-of-function escargot mutations. Hekmat-Scafe DS, et al. Genetics, 2005 Mar. PMID 15654097, Free PMC Article
    4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    5. Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. Egger B, et al. Development, 2002 Jul. PMID 12091301

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase 6
    Names
    Alp6-PA
    CG1809-PA
    NP_610496.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9561638..9563871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136652.3 → NP_610496.1  alkaline phosphatase 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3X8
      Related
      FBpp0087603
      Conserved Domains (1) summary
      cl23718
      Location:72 → 511
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3X8 Q7K3X8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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