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    GAA1 Glycosylphosphatidylinositol anchor attachment 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAA1provided by FlyBase
    Official Full Name
    Glycosylphosphatidylinositol anchor attachment 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029818
    Locus tag
    Dmel_CG3033
    See related
    AllianceGenome:FB:FBgn0029818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3033; Dmel\CG3033; GPAA1
    Summary
    Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Located in endomembrane system. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to human GPAA1 (glycosylphosphatidylinositol anchor attachment 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GAA1 in Genome Data Viewer
    Location:
    5C5-5C5; 1-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5870841..5873357, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5764874..5767390, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene males absent on the first Neighboring gene Ubiquitin specific protease 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
    2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
    3. Enhanced nucleotide chemistry and toehold nanotechnology reveals lncRNA spreading on chromatin. Machyna M, et al. Nat Struct Mol Biol, 2020 Mar. PMID 32157249
    4. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Kind J, et al. Genes Dev, 2007 Aug 15. PMID 17699750, Free PMC Article
    5. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhabdomere membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycosylphosphatidylinositol anchor attachment 1
    Names
    CG3033-PA
    GAA1-PA
    glycosylphosphatidylinositol anchor attachment 1 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5870841..5873357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132045.4 → NP_572273.2  glycosylphosphatidylinositol anchor attachment 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572273.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8B2, Q9W464
      Related
      FBpp0070795
      Conserved Domains (1) summary
      pfam04114
      Location:127 → 639
      Gaa1; Gaa1-like, GPI transamidase component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961V1 Q961V1
    Q9W464 Q9W464

    Gene LinkOut

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