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    Bap170 Brahma associated protein 170kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bap170provided by FlyBase
    Official Full Name
    Brahma associated protein 170kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042085
    Locus tag
    Dmel_CG3274
    See related
    AllianceGenome:FB:FBgn0042085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BAP 170; bap170; BAP170; BcDNA:GH12174; CG3274; Dmel\CG3274; hfl
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; positive regulation of DNA-templated transcription; and protein stabilization. Part of brahma complex. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bap170 in Genome Data Viewer
    Location:
    42B2-42B2; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6636512..6642358)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2524017..2529863)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 16kD subunit 1 Neighboring gene Trap1 Neighboring gene Flavin-containing monooxygenase 2 Neighboring gene Death executioner Bcl-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription. Judd J, et al. Genes Dev, 2021 Jan 1. PMID 33303640, Free PMC Article
    2. Kinetic principles underlying pioneer function of GAGA transcription factor in live cells. Tang X, et al. Nat Struct Mol Biol, 2022 Jul. PMID 35835866, Free PMC Article
    3. Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease. Costa AC, et al. Cell Death Dis, 2013 Jan 17. PMID 23328674, Free PMC Article
    4. Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control. Moshkin YM, et al. Mol Cell Biol, 2007 Jan. PMID 17101803, Free PMC Article
    5. MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes. Nikolenko JV, et al. Dokl Biochem Biophys, 2021 May. PMID 33689064

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
      Title: Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.
    2. Bap170 participates instead in the negative regulation of EGFR signaling
      Title: Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling.
    3. BAP170 and BAP180 act redundantly to allow metamorphosis gene expression profiling of bap170 bap180 double mutants, showed that the PBAP complex regulates genes involved in tissue remodeling and immune system function.
      Title: Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.
    4. Results report the identification of two novel BRM complex-associated proteins: Drosophila Polybromo and BAP170, a conserved protein not described previously.
      Title: Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SWI/SNF superfamily-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brahma associated protein 170kD
    Names
    Bap170-PA
    CG3274-PA
    half-life

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6636512..6642358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136372.4 → NP_610216.1  brahma associated protein 170kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6M0
      Related
      FBpp0085442
      Conserved Domains (2) summary
      pfam01388
      Location:69 → 152
      ARID; ARID/BRIGHT DNA binding domain
      pfam02257
      Location:677 → 761
      RFX_DNA_binding; RFX DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6M0 A1Z6M0
    Q7KMJ0 Q7KMJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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