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    CG11899 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11899provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014427
    Locus tag
    Dmel_CG11899
    See related
    AllianceGenome:FB:FBgn0014427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    39C10S; anon-sts29; Dmel\CG11899; ESTS:39C10S; Ov8
    Summary
    Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11899 in Genome Data Viewer
    Location:
    99A1-99A1; 3-98 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29200454..29201770)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25026176..25027492)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene julius seizure Neighboring gene uncharacterized protein Neighboring gene Cytochrome c1-like Neighboring gene Metazoan SpoT homolog-1 Neighboring gene long non-coding RNA::CR31044 Neighboring gene mir-279 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila. Wang R, et al. Nat Commun, 2022 Jun 20. PMID 35725845, Free PMC Article
    2. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Sun D, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818390
    3. A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine. Russi M, et al. Hum Mol Genet, 2020 Oct 10. PMID 32744307
    4. Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. Schirling C, et al. Chromosoma, 2010 Feb. PMID 19949809
    5. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-serine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11899-PA
    NP_652046.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29200454..29201770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143789.3 → NP_652046.1  uncharacterized protein Dmel_CG11899 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652046.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3YMT6, Q9VAN0
      Related
      FBpp0084759
      Conserved Domains (1) summary
      cd00611
      Location:3 → 360
      PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAN0.1 Q9VAN0

    Gene LinkOut

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