U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    bigmax bigmax [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43293, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bigmaxprovided by FlyBase
    Official Full Name
    bigmaxprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039509
    Locus tag
    Dmel_CG3350
    See related
    AllianceGenome:FB:FBgn0039509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHd13; Bigmax; BIGMAX; cg3350; CG3350; Dmel\CG3350; DmMlx; mlx; Mlx
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in adult feeding behavior; positive regulation of transcription by RNA polymerase II; and response to glucose. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See bigmax in Genome Data Viewer
    Location:
    97F1-97F1; 3-93 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27287366..27288526, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23113088..23114248, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene martik Neighboring gene uncharacterized protein Neighboring gene Hemomucin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44287

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Sassu ED, et al. Biochem Biophys Res Commun, 2012 Sep 14. PMID 22910416, Free PMC Article
    2. Salt-Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH/NADP(+) Redox Balance. Teesalu M, et al. Curr Biol, 2017 Feb 6. PMID 28132818
    3. Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species. Watanabe K, et al. Cell Rep, 2019 Sep 3. PMID 31484071
    4. Transforming Growth Factor β/Activin signaling in neurons increases susceptibility to starvation. Chng WA, et al. PLoS One, 2017. PMID 29084242, Free PMC Article
    5. Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis. Melvin RG, et al. Elife, 2018 Nov 27. PMID 30480548, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mondo-Mlx maintains metabolic homeostasis through Activin ligand Dawdle and the Gli-similar transcription factor Sugarbabe.
      Title: Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    bigmax
    Names
    CG3350-PA
    Max-like protein X
    big max
    bigmax-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27287366..27288526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143299.3 → NP_651556.2  bigmax [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651556.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GQP6, Q9VB47
      Related
      FBpp0084543
      Conserved Domains (1) summary
      cd00083
      Location:69 → 130
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GQP6 Q9GQP6
    Q9VB47 Q9VB47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools