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    CG5445 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5445provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030838
    Locus tag
    Dmel_CG5445
    See related
    AllianceGenome:FB:FBgn0030838
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5445
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in macroautophagy. Predicted to be active in phagophore assembly site. Is expressed in organism. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5445 in Genome Data Viewer
    Location:
    15F7-16A1; 1-57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17282496..17305475)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17176529..17199508)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene forked Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fimbrin Neighboring gene BarH2 Neighboring gene long non-coding RNA:CR43491

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila. Uechi H, et al. Mol Cell Biol, 2018 Feb 1. PMID 29109084, Free PMC Article
    2. Amyotrophic Lateral Sclerosis Genes in Drosophila melanogaster. Layalle S, et al. Int J Mol Sci, 2021 Jan 18. PMID 33477509, Free PMC Article
    3. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Nagarkar-Jaiswal S, et al. Elife, 2015 Mar 31. PMID 25824290, Free PMC Article
    4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
    5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5445-PA
    CG5445-PB
    CG5445-PD
    CG5445-PF
    CG5445-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17282496..17305475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298442.1 → NP_001285371.1  uncharacterized protein Dmel_CG5445, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX56
      Conserved Domains (2) summary
      cd14349
      Location:129 → 170
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cl22423
      Location:197 → 261
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    2. NM_176748.2 → NP_788921.1  uncharacterized protein Dmel_CG5445, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX56
      Related
      FBpp0074202
      Conserved Domains (2) summary
      cd14349
      Location:129 → 170
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cl22423
      Location:197 → 261
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    3. NM_132985.4 → NP_573213.1  uncharacterized protein Dmel_CG5445, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX56
      Related
      FBpp0074201
      Conserved Domains (2) summary
      cd14349
      Location:129 → 170
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cl22423
      Location:197 → 261
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    4. NM_167568.3 → NP_728077.1  uncharacterized protein Dmel_CG5445, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX56
      Related
      FBpp0308824
      Conserved Domains (2) summary
      cd14349
      Location:129 → 170
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cl22423
      Location:197 → 261
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    5. NM_167567.2 → NP_728076.1  uncharacterized protein Dmel_CG5445, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX56
      Related
      FBpp0074199
      Conserved Domains (2) summary
      cd14349
      Location:129 → 170
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cl22423
      Location:197 → 261
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX56 Q9VX56

    Gene LinkOut

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