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    p120ctn p120 catenin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    p120ctnprovided by FlyBase
    Official Full Name
    p120 cateninprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260799
    Locus tag
    Dmel_CG17484
    See related
    AllianceGenome:FB:FBgn0260799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17484; Dmel\CG17484; dp120ctn; dP120ctn; Dp120ctn; Dp120[ctn]; p120; P120; P120-catenin; P120ctn; p120[ctn]
    Summary
    Predicted to enable cadherin binding activity. Involved in several processes, including adherens junction maintenance; compound eye morphogenesis; and dendritic spine morphogenesis. Located in adherens junction; centrosome; and cytoplasm. Is expressed in several structures, including epithelium; follicle cell; ganglia; gut section; and presumptive embryonic/larval system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; anxiety disorder; arrhythmogenic right ventricular cardiomyopathy (multiple); blepharocheilodontic syndrome 2; and major depressive disorder. Orthologous to several human genes including PKP4 (plakophilin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See p120ctn in Genome Data Viewer
    Location:
    41B1-41B1; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4595288..4609492)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (482793..496997)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L38 Neighboring gene Ste20-like kinase Neighboring gene downstream non-coding target of Rpd3 and Loco Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Delta-catenin at the synaptic-adherens junction. Kosik KS, et al. Trends Cell Biol, 2005 Mar. PMID 15752981
    2. Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Li W, et al. Dev Dyn, 2005 Nov. PMID 16003769
    3. Binding site for p120/delta-catenin is not required for Drosophila E-cadherin function in vivo. Pacquelet A, et al. J Cell Biol, 2003 Feb 3. PMID 12551956, Free PMC Article
    4. Drosophila p120-catenin is crucial for endocytosis of the dynamic E-cadherin-Bazooka complex. Bulgakova NA, et al. J Cell Sci, 2016 Feb 1. PMID 26698216, Free PMC Article
    5. Feedback regulation of steady-state epithelial turnover and organ size. Liang J, et al. Nature, 2017 Aug 31. PMID 28847000, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel role for dp120ctn in the regulation of animal stress response and immune signalling.
      Title: p120 catenin is required for the stress response in Drosophila.
    2. alpha-catenin and p120(ctn) are key players in a mechanism of recruiting Rho1 to its sites of action.
      Title: Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila.
    3. p120 catenin (p120 ctn) primarily enhances the development of spine-like protrusions.
      Title: Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 4596613-4596862 mobile_element_type = transposon:INE-1{}3191
    • Loc: 4597083-4597626 mobile_element_type = transposon:INE-1{}3194
    • Loc: 4602193-4602470 mobile_element_type = transposon:INE-1{}3197
    • Loc: 4605020-4605787 mobile_element_type = transposon:diver2{}2735

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in adherens junction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    p120 catenin
    Names
    Adherens-junction-protein-p120
    CG17484-PA
    P120-Catenin
    adherens junction protein p120
    p120catenin
    p120ctn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4595288..4609492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042979.2 → NP_001036444.1  p120 catenin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLI0, Q9NHP1
      Conserved Domains (2) summary
      cd00020
      Location:227 → 341
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:227 → 252
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7PLI0 Q7PLI0
    Q8T0H3 Q8T0H3
    Q9NHP1 Q9NHP1

    Gene LinkOut

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