Gug Grunge [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gugprovided by FlyBase
Official Full Name: Grungeprovided by FlyBase
Primary source: FLYBASE:FBgn0010825
Locus tag: Dmel_CG6964
See related: AllianceGenome:FB:FBgn0010825
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atro; Atro; CG6964; Dmel\CG6964; gug; GUG; l(3)01323; l(3)03928; l(3)j5A3; l(3)rO116; l(3)S146907
Summary: Enables nuclear receptor binding activity and transcription corepressor activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; inter-male aggressive behavior; and negative regulation of signal transduction. Located in nucleus and polytene chromosome interband. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval optic lobe; ganglia; imaginal disc; and larval central nervous system. Used to study dentatorubral-pallidoluysian atrophy. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human RERE (arginine-glutamic acid dipeptide repeats) and ATN1 (atrophin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66C13-66D1; 3-26 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8449922..8472669)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8443022..8465769)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gug is required for memory retention and social learning.
Title: Machine Learning Analysis Identifies Drosophila Grunge/Atrophin as an Important Learning and Memory Gene Required for Memory Retention and Social Learning.
Taken together, these data indicate that Atrophin is a major Trithorax-like cofactor that functions to moderate developmental gene transcription.
Title: Atrophin controls developmental signaling pathways via interactions with Trithorax-like.
the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
Title: Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR.
Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat.
Title: Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat.
Drosophila Atro promote neurodegeneration with autophagic hallmarks both in neuronal photoreceptors and glial cells.
Title: Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.
Data show that the conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.
Title: The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.
Atrophin genetically cooperates with the nuclear repressor Yan to inhibit the EGFR signaling activity.
Title: Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila.
These data lead us to a model in which fat and Atro act twice in the determination of planar polarity in the eye: first in setting up positional information through the production of a planar polarity diffusible signal, and later in R3 fate determination
Title: The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.
Atro appears to be particularly closely related in function to the trxG gene osa, which encodes a component of the brahma chromatin remodeling complex.
Title: A screen for genes that interact with the Drosophila pair-rule segmentation gene fushi tarazu.
mutations in Atro and Sbb have similar phenotypes, including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with Atro to provide repressive activity
Title: Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0378 (e-PCR)
- UniSTS:460

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	HMP more info	PubMed
involved_in segmentation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: grunge

Names: CG6964-PA; CG6964-PC; CG6964-PD; CG6964-PE; CG6964-PF; CG6964-PG; CG6964-PH; CG6964-PI; CG6964-PJ; Gug-PA; Gug-PC; Gug-PD; Gug-PE; Gug-PF; Gug-PG; Gug-PH; Gug-PI; Gug-PJ; atrophin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8449922..8472669

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079249.3 → NP_523973.2 grunge, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523973.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9N4, Q9VSK5

Related

FBpp0296979

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_001274652.1 → NP_001261581.1 grunge, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261581.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHT1, Q8T9N4

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_206303.2 → NP_996025.1 grunge, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996025.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KUA8, Q8T9N4

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_001259742.1 → NP_001246671.1 grunge, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246671.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDL9, Q8T9N4

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_001274651.1 → NP_001261580.1 grunge, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261580.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PES2, Q8T9N4

Conserved Domains (4) summary

smart00717
Location:120 → 167

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:121 → 166

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:339 → 435

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 63

ELM2; ELM2 domain
NM_001259741.1 → NP_001246670.1 grunge, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246670.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KUA8, Q8T9N4

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_001259743.1 → NP_001246672.1 grunge, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246672.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE54, Q8T9N4

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_176300.1 → NP_788478.1 grunge, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788478.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BH2, Q8T9N4

Related

FBpp0076345, FBtr0076618

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain
NM_145106.1 → NP_659574.1 grunge, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_659574.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQA6, Q9NHX6

Related

FBpp0076343, FBtr0076616

Conserved Domains (4) summary

smart00717
Location:125 → 172

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:126 → 171

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

TIGR04420
Location:344 → 440

Sec_Non_Glob; Sec region non-globular protein

pfam01448
Location:9 → 68

ELM2; ELM2 domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
M9NDL9		M9NDL9
M9NE54		M9NE54
M9PES2		M9PES2
M9PHT1		M9PHT1
Q7KUA8		Q7KUA8
Q86BH2		Q86BH2
Q8IQA6		Q8IQA6
Q8MQW5		Q8MQW5
Q8T090		Q8T090
Q8T9N4		Q8T9N4
Q9NHX6		Q9NHX6
Q9VSK5		Q9VSK5